Summary
In Bufo bufo japonicus catecholamine neurons in the preoptic recess organ (PRO) became detectable at the metamorphic climax by formaldehyde-induced fluorescence (Falck-Hillarp technique). In hypophysectomized tadpoles metamorphosis was inhibited and no fluorescent neurons appeared in the PRO. Implantation of a pituitary graft to the hypophysectomized tadpoles induced metamorphosis and development of PRO catecholamine neurons. Administration of corticosterone to hypophysectomized tadpoles resulted in the development of PRO catecholamine neurons in spite of the unmetamorphosed state. On the other hand, prolactin administration had no effect on the PRO neurons of hypophysectomized tadpoles. From these results, in conjunction with our previous results indicating that thyroxine treatment induces development of the PRO catecholamine neurons in thyroidectomized animals but not in hypophysectomized animals, it is concluded that corticosterone is a primary hormone for the development of PRO catecholamine neurons in toad tadpoles.
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References
Braak H (1970) Biogene Amine im Gehirn vom Frosch (Rana esculenta). Z Zellforsch 106:269–308
Carstensen H, Burgers ACJ, Li CH (1961) Demonstration of aldosterone and corticosterone as the principal steroids formed in incubates of adrenals of the American bullfrog Rana catesbeiana and stimulation of their production by mammalian adrenocorticotropin. Gen Comp Endocrinol 1:37–50
Chacko T, Terlou M, Peute J (1974) Fluorescence and electron micrroscopical study of aminergic nuclei in the brain of Bufo poweri. Cell Tissue Res 149:481–495
Clemons GK, Nicoll CS (1977) Development and preliminary application of a homologus radio immunoassay for bullfrog prolactin. Gen Comp Endocrinol 32:531–535
Doupe AJ, Patterson PH (1982) Glucocorticoids and the developing nervous system. In: Ganten D, Pfaff D (eds) Adrenal actions on brain. Springer, Berlin Heidelberg New York
Hsu CY, Yu NW, Chen SJ (1980) Development of Δ5-3β-hydroxy-steroid dehydrogenase activity in the interrenal gland of Rana catesbeiana. Gen Comp Endocrinol 42:167–170
Jaffe RC (1981) Plasma concentration of corticosterone during Rana catesbeiana tadpole metamorphosis. Gen Comp Endocrinol 44:314–318
Jolivet-Jaudet G (1982) Etude de la fonction inerrenalienne pendant la metamorphose du tetard de Xenopus laevis. Thesis, Univ. Pierre et Marie Curie, Paris
Kikuyama S, Miyakawa M, Arai Y (1979) Influence of thyroid hormone on the development of preoptic-hypothalamic monoaminergic neurons in tadpoles of Bufo bufo japonicus. Cell Tissue Res 198:27–33
Krug EC, Honn KV, Battista J, Nicoll CS (1983) Corticosteroids in serum of Rana catesbeiana during development and metamorphosis. Gen Comp Endocrinol 52:232–241
Macchi IA, Phillip JG (1966) In vitro effect of adrenocorticotropin on corticosteroid secretion in the turtle, snake and bullfrog. Gen Comp Endocrinol 6:170–182
Markey KA, Towle AC, Sze PY (1982) Glucocorticoid influence on tyrosine hydroxylase activity in mouse locus coeruleus during postnatal development. Endocrinology 111:1519–1523
Miyakawa M, Arai Y, Kikuyama S (1978) Monoamine-containing neurons in diencephalon of toad tadpoles. Zool Mag 87:464
Moore KE, Demarest KT (1982) Tuberoinfundibular and tuberohypophyseal dopaminergic neurons. In: Ganong WF, Martini L (eds) Frontiers in neuroendocrinology, vol. 7. Raven Press, New York
Prasada Rao PD, Hartwig HG (1974) Monoaminergic tracts of the diencephalon and innervation of the pars intermedia in Rana temporaria. Cell Tissue Res 151:1–26
Terlou M, Ploemacher RE (1973) The distribution of monoamines in the tel-, di- and mesencephalon of Xenopus laevis tadpoles, with special reference to the hypothalamo-hypophysial system. Z Zellforsch 137:521–540
Yamamoto K, Kikuyama S (1982) Radioimmunoassay of prolactin in plasma of bullfrog tadpoles. Endocrinol Jpn 29:159–167
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Miyakawa, M., Arai, Y. & Kikuyama, S. Corticosterone stimulates the development of preoptic catecholamine neurons in tadpoles Bufo bufo japonicus . Anat Embryol 170, 113–115 (1984). https://doi.org/10.1007/BF00318994
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DOI: https://doi.org/10.1007/BF00318994