Abstract
T 2 toxin (T 2), diacetoxyscirpenol (DAS), fusarenon X (FX) and butenolide (Bd) at concentrations of 0.2, 0.3, 5 and 10 μg/site, respectively, were applied individually and in combinations on shaved skin of guinea pigs. Erythema and induration were observed on skin patches treated with the toxins. Increase in the thickness of stratum malpighii was the major histological change observed. Mild to moderate degeneration of fibrocytes and cellular infiltration were found in the corium of skin treated with FX, Bd, DAS and T 2. The order of toxicity of individual toxins was T 2 > DAS > FX > Bd. Combinations of T 2 + FX and T 2 + Bd resulted in antagonism, while DAS + FX and DAS + Bd caused synergism.
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References
Bamburg JR (1969) PhD Thesis, University of Wisconsin, Madison, Wisconsin
Bhavanishanker TN, Shantha T (1987) Natural occurrence of Fusarium toxins in peanut, sorghum and maize from Mysore (India). J Sci Food Agric 40: 327–332
Dutton MF, Westlake K (1985) Occurrence of mycotoxins in cereals and animal feedstuffs in Natal, South Africa. J Assoc Off Anal Chem 68: 839–842
El-Kady IA, El-Maraghy SS (1982) Screening of zearalenone-producing Fusarium species in Egypt and chemically defined medium for production of the toxin. Mycopathologia 78: 25–29
Hayes MA, Schiefer HB (1979) Quantitative and morphological aspects of cutaneous irritation by trichothecene mycotoxins. Food Cosmet Toxicol 17: 611–621
Hoerr FJ, Carlton WW, Yagen B (1981) The toxicity of T 2 toxin and diacetoxyscirpenol in combination for broiler chickens. Food Cosmet Toxicol 19: 185–188
Joffe AZ (1971) Alimentary toxic aleukia. In: Kadis S, Ciegler A, Ajl SJ (eds) Microbial toxins, vol VII. Academic Press, New York, p 139
Marasas WFO, Leistner L, Hofmann G, Eckardt C (1979) Occurrence of toxigenic strains of Fusarium in maize and barley in Germany. Eur J Appl Microbiol Biotechnol 7: 289–305
McDonald D (1970) Fungal infection of groundnut fruit before harvest. Trans Br Mycol Soc 54: 453–460
Mirocha CJ, Pathre SV, Schauerhamer B, Christensen CM (1976) Natural occurrence of Fusarium toxins in feedstuff. Appl Environ Microbiol 32: 553–556
Morooka N, Uratsuji V, Yoshizawa T, Yamamoto H (1972) Studies on the toxic substances in barley infected with Fusarium spp. Jpn J Food Hyg 13: 368–375
Sato N, Ueno Y (1977) Comparative toxicities of trichothecenes. In: Rodricks J, Hesseltine CW, Mehlman MA (eds) Mycotoxins in human and animal health. Pathotox Publishers Inc, Ill, pp 295–307
Seaman WL (1982) Epidemiology and control of mycotoxigenic fusaria on cereal grains. Can J Plant Pathol 4: 187–190
Szathmary CI (1983) Trichothecene toxicoses and natural occurrence in Hungary. In: Ueno Y (ed) Trichothecene — chemical, biological and toxicological aspects. Elsevier, Amsterdam Oxford New York, p 229
Ueno Y (1983) General toxicology. In: Ueno Y (ed) Trichothecene — chemical, biological and toxicological aspects. Elsevier, Amsterdam Oxford New York, p 135
Ueno Y, Ishikawa Y, Amakai K, Nakajima M, Saito M, Enomoto M, Ohtsubo K (1970) Comparative study of skin-necrotizing effect of scirpene metabolites of Fusaria. Jpn J Exp Med 40: 33–38
Vesonder RF, Ciegler A, Jensen AH, Rohwedder WK, Weisleder D (1976) Co-identity of the refusal and emetic principles from Fusarium infected corn. Appl Environ Microbiol 31: 280–285
Yates SG (1971) Toxin producing fungi from fescue pasture. In Kadis S, Ciegler A, Ajl SJ (eds) Microbial toxins, vol VII. Academic Press, New York, p 191
Yates SG, Tookey HL, Ellis JJ, Burkhardt HJ (1968) Mycotoxins produced by Fusarium nivale isolated from tall fescue (Festuca arundinacea Sch.) Phytochemistry 7: 139–146
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Bhavanishankar, T.N., Ramesh, H.P. & Shantha, T. Dermal toxicity of Fusarium toxins in combinations. Arch Toxicol 61, 241–244 (1988). https://doi.org/10.1007/BF00316641
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DOI: https://doi.org/10.1007/BF00316641