Abstract
Experimental manganese encephalopathy was produced in rabbits by intratracheal inoculation of manganese dioxide (400 mg). After a period of 18 to 24 months manganese inoculated rabbits developed paralysis of the hind limbs. There was widespread neuronal loss and neuronal degeneration in cerebral cortex, caudate nucleus, putamen, substantia nigra and cerebellar cortex. This was associated with neuroglial proliferation.
There was marked reduction in the activity of acid phosphatase and adenosine triphosphatase in the degenerated neurones in manganese inoculated animals as compared to controls. No alteration was observed in the activity of alkaline phosphatase and 5′-nucleotidase. It has been suggested that manganese may possibly have an inhibitory effect on acid phosphatase and adenosine triphosphatase in affected neurones by disturbing the catabolism of enzyme protein or by destroying lysosomes and mitochondria.
Zusammenfassung
An Kaninchen wurde durch intratracheale Instillation von 400 mg Mangandioxid eine experimentelle Mangan-Encephalopathie erzeugt. 18 bis 24 Monate danach entwickelte sich bei den Kaninchen eine Lähmung der Hinterläufe. In der Hirnrinde, im Nucleus caudatus, Putamen, Substantia nigra und Kleinhirnrinde fand sich ausgedehnt Untergang und Degeneration von Neuromen. Er war vergesellschaftet mit Proliferation der Neuroglia.
Die Aktivität der sauren Phosphatase und Adenosintriphosphatase in den degenierten Neuronen war deutlich vermindert, verglichen mit Kontrollen. Dagegen fand sich keine Veränderung der Aktivität von alkalischer Phosphatase und 5′-Nucleotidase. Es wird vermutet, daß Mangan die saure Phosphatase und Adenosintriphosphatase in den betroffenen Neuronen hemmt durch Störung des Katabolismus von Enzymprotein oder durch Zerstörung von Lysosomen und Mitochondrien.
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Chandra, S.V. Histological and histochemical changes in experimental manganese encephalopathy in rabbits. Arch Toxicol 29, 29–38 (1972). https://doi.org/10.1007/BF00316512
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DOI: https://doi.org/10.1007/BF00316512