Abstract
Acetylcholinesterase activity in 27 areas of the dog brain was studied after i.v. infusion of O-ethyl-S-(2-dimethyl-aminoethyl) methylphosphonothioate, administered 20.0 μg/kg per 10 min. This activity was significantly decreased in all brain parts studied; the greatest decrease was observed in the nucleus nervi vagi, hypoglossi and in the colliculus superior.
Zusammenfassung
In 27 Arealen des Hundegehirns wurde die Aktivität der Acetylcholinesterase nach i.v.-Infusion von O-Aethyl-S-(2-dimethylaminoaethyl)-methylphosphonothioat (20.0 μg/kg innerhalb 10 min) gemessen. In allen untersuchten Hirnpartien war die AChE-Aktivität signifikant vermindert; die stärkste Hemmung wurde in den Kernen des Nervus vagus und hypoglossus sowie im Colliculus superior beobachtet.
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Bajgar, J., Urban, R. & Hrdina, V. Hemmung der Acetylcholinesterase in 27 Abschnitten des Hundegehirns durch O-Aethyl-S-(2-dimethylaminoaethyl)-methylphosphonothioat in vivo . Arch Toxicol 29, 247–253 (1972). https://doi.org/10.1007/BF00315602
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DOI: https://doi.org/10.1007/BF00315602