Summary
We have studied the pharmacokinetics of phenprocoumon with and without co-administration of frusemide and probenecid in two groups of 17 healthy volunteers.
Frusemide 40 mg b.i.d. for 7 days did not interact with phenprocoumon to a significant extent. Probenecid 500 mg q.i.d. for 7 days significantly accelerated the overall elimination of phenprocoumon, as indicated by a decrease in AUC from 295 to 157 μg · h · ml−1, and a reduction in the fraction of the dose excreted by the kidneys.
The data are consistent with inhibition of the glucronidation of phenprocoumon by probenecid. Its accelerated elimination may be a consequence of the increased formation of hydroxylated metabolites.
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Mönig, H., Böhm, M., Ohnhaus, E.E. et al. The effects of frusemide and probenecid on the pharmacokinetics of phenprocoumon. Eur J Clin Pharmacol 39, 261–265 (1990). https://doi.org/10.1007/BF00315107
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DOI: https://doi.org/10.1007/BF00315107