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Acute prenylamine poisoning

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Abstract

A 58-year-old man ingested 900 mg prenylamine with the intention of suicide. Several hours later he developed a gastrointestinal reaction, considerable weakness, vertigo, and recurrent syncope.

ECG records revealed sinus bradycardia with numerous premature nodal and auricular beats and disturbances in depolarization and polarization of ventricles.

The administration of Alupent in a dose of 15 mg/day produced recession of the clinical and electrocardiographic changes.

Zusammenfassung

Ein 58jähriger Mann hat in suicidaler Absicht peroral 900 mg Prenylamine aufgenommen. Einige Stunden nach der Aufnahme traten gastroenterale Erscheinungen, beträchtliche Entkräftung, Schwindel und wiederholte Ohnmachtszustände auf.

Im EKG wurde Sinusbradykardie mit zahlreichen zusätzlichen Nodus- und Vorhofextrasystolen, Depolarisations und Polarisationsstörungen der Kammern festgestellt.

Die Verabreichung von Alupent® 15 mg täglich hat zum Abklingen von klinischen und EKG-Symptomen geführt.

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Lewandowicz, J., Starzyński, Z. Acute prenylamine poisoning. Arch. Toxicol. 31, 217–222 (1974). https://doi.org/10.1007/BF00311054

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