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Selective potentiations in opioid analgesia following scopolamine pretreatment

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Abstract

The effects of the muscarinic receptor antagonist scopolamine upon analgesia induced by d-ala-d-leu-enkephalin (DADL), beta-endorphin (BEND) and morphine were examined. While scopolamine (10 mg/kg, IP) significantly potentiated the analgesic responses following DADL (40 μg, ICV) and morphine (5 mg/kg, SC) on the jump test, it failed to alter significantly BEND (1 μg, ICV) analgesia.

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Authors and Affiliations

  1. Department of Psychology, Queens College, CUNY, 11367, Flushing, NY, USA

    Ellen S. Sperber, Maria-Teresa Romero & Richard J. Bodnar

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  1. Ellen S. Sperber
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  2. Maria-Teresa Romero
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  3. Richard J. Bodnar
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Sperber, E.S., Romero, MT. & Bodnar, R.J. Selective potentiations in opioid analgesia following scopolamine pretreatment. Psychopharmacologia 89, 175–176 (1986). https://doi.org/10.1007/BF00310624

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  • DOI: https://doi.org/10.1007/BF00310624

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