Abstract
δ-Aminolevulinic acid (ALA) synthetase, δ-ALA dehydratase and heme oxygenase activities were studied in the liver of albino rats, 3 and 20 h after i.p. administration of benzene, gasoline, and kerosene. δ-ALA synthetase activity was increased markedly after benzene administration, while gasoline and kerosene treated groups showed decreased enzyme activity. Inhibition of δ-ALA dehydratase activity was observed in all three groups, but heme oxygenase activity was unchanged.
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References
De Matteis F (1972) Mechanisms of induction of hepatic porphyria by drugs. Pharmacology and future of man. Proceedings 5th International Congress of Pharmacology, San Francisco, vol 2. Karger, Basel, pp 89–99
De Matteis F, Sparks RG (1973) Iron-dependent loss of liver cytochrome P-450 heme in vivo and in vitro. FEBS Lett 29: 141–144
Freedman ML, Wildman JM, Rosman J, Eisen J, Greenblatt DR (1977) Benzene inhibition of in vitro rabbit reticulocyte heme synthesis at δ-ALA synthetase: Reversal of benzene toxicity by pyridoxine. Br J Haematol 35: 49–60
Gibson KD, Neuberger A, Scott JJ (1955) The purification and properties of δ-aminolevulinic acid dehydratase. Biochem J 61: 618–629
Granick S, Urata G (1963) Increase in activity of δ-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3,5-dicarbethoxy-1,4-dihydrocollidine. J Biol Chem 238: 821–827
Jeelani Dhar G, Bossenmaier I, Petryka ZJ, Cardinal R, Watson CJ (1975) Effects of hematin in hepatic porphyria. Ann Intern Med 83: 20–30
Jerina DM, Daly JW (1974) Arene oxides: A new aspect of drug metabolism. Science 185: 573–582
Khan H, Muzyka V (1973) The chronic effect of benzene on porphyrin metabolism. Work-Environ Health 10: 140–143
Khan S, Pandya KP (1978) Ferrokinetics of Fe59 in octane and benzene administered rats. A Soc Biol Chem (India) 267: 112
Lee EW, Kocsis J, Snyder R (1973) Dose dependent inhibition of Fe59 incorporation into erythrocytes after a single dose of benzene. Res Commun Chem Pathol Pharmacol 5: 547–549
Maines MD, Kappas A (1976) Tin: A potent inducer of heme oxygenase in kidney. Science 192: 60–62
Marver HS, Tschudy DP, Perlroth MG, Collins A (1966a) δ-Aminolevulinic acid synthetase. Studies in liver homogenates. J Biol Chem 241: 2803–2809
Marver HS, Collins A, Tschudy DP, Recheigl M Jr (1966b) δ-Aminolevulinic acid synthetase. Induction in rat liver. J Biol Chem 241: 4323–4329
Nakoo K, Wada O, Takaku F, Sassa S, Yano Y, Urata G (1967) The origin of increased protoporphyrin in erythrocytes of mice with experimentally induced porphyria. J Lab Clin Med 70: 923–932
Rao GS, Pandya KP (1978) Toxicity of petroleum products. Effect of alkaline phosphatase and lipid peroxidation. Environ Res 16: 174–178
Rao GS, Kala A, Pandya KP (1978) Excretion of δ-aminolevulinic acid by workers handling petrol. Indian J Biochem Biophys (Suppl) 16: 60
Rao GS, Pandya KP (1979) Effect of benzene, gasoline and kerosene on δ-ALA-dehydratase in liver and kidney of albino rats. A Soc Biol Chem (India) P6 XII: 142
Snyder R, Kocsis JJ (1975) Current concepts of chronic benzene toxicity. CRC Crit Rev Toxicol 3: 265–288
Snyder R, Lee EW, Kocsis JJ, Witmer C (1977) Bone marrow depressant and leukemogenic action of benzene. Life Sci 21: 1709–1722
Snyder R, Lee EW, Kocsis JJ (1978) Binding of labeled benzene metabolites to mouse liver and bone marrow. Res Commun Chem Pathol Pharmacol 20: 191–194
Srivastava RC, Khan S, Uma S, Pandya KP (1979) Distribution of Fe59 in benzene and iomex treated rats. Arch Toxicol 42: 43–49
Woods JS, Fowler BA (1978) Altered regulation of mammalian hepatic heme biosynthesis and urinary porphyrin excretion during prolonged exposure to sodium arsenate. Toxicol Appl Pharmacol 43: 361–371
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Rao, G.S., Pandya, K.P. Hepatic metabolism of heme in rats after exposure to benzene, gasoline and kerosene. Arch Toxicol 46, 313–317 (1980). https://doi.org/10.1007/BF00310449
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DOI: https://doi.org/10.1007/BF00310449