Abstract
A delayed localized neuropathy of peripheral nerves in a single hind leg of the cat develops after a single intraarterial 2 mg/kg injection of diisopropylfluorophosphate (DFP). This neuropathy is manifested by a maximum loss of the capacity of soleus α-motor nerve terminals to generate stimulus-bound repetition 21 days after DFP exposure. Phenylmethanesulfonyl fluoride (PMSF) is a protective inhibitor of the neurotoxic esterase which is associated with the development of the delayed organophosphorus neuropathy. Pretreatment of cats with PMSF (30 mg/kg i.p.) 24 h before the DFP injection protected the cats from the delayed neuropathy. No clinical neurotoxic signs were observed at 21 days after DFP. The stimulus-bound repetitive capacity of soleus α-motor nerve terminals was not lost at this time and its incidence was much greater than that which occurred in cats not pretreated with PMSF.
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This work was supported by U.S. Public Health Service National Institute for Neurological and Communicative Diseases and Stroke Grants NS-01447 and NS-11948
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Baker, T., Lowndes, H.E., Johnson, M.K. et al. The effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy. Arch Toxicol 46, 305–311 (1980). https://doi.org/10.1007/BF00310448
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DOI: https://doi.org/10.1007/BF00310448