Abstract
Pituitaries from 25 senile untreated Beagle bitches aged 7–11 years, have been examined using a specific staining technique. In 10 out of 25 animals (40%), pituitary adenomas were detected. In general, pituitary neoplasms were observed as small nodules (2–3.5 mm in diameter) during gross examination or as incidental findings during the microscopic examination.
Histological examination showed that the adenomas observed during gross examination were made up either of ACTH cells or of a combination of ACTH and immature cells; the adenomas which were observed as incidental findings during microscopic examination were made up of ACTH, immature or intermediate zone cells.
The possible histogenesis of pituitary adenomas, especially the immature cell adenoma, is discussed.
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References
Attia MA (1978) Modified tetrachrome staining technique for the adenohypophysis of dogs, rats and rabbits. Arch Toxicol 40: 295–301
Brandt AJ (1940) Über Hypophysenadenome bei Hund und Pferd. Skand Vet Tidskr 30: 875–915
Capen CC, Martins SL, Koestner A (1967) Neoplasms in the adenohypophysis of dogs. Pathol Vet 4: 301–375
Fankhouser R, Wyler R (1954) Chromophobs Adenom der Hypophyse bei einem Hund. Schweiz Arch Tierheilkd 96: 181–188
Kovacs K, Bachrach D (1954) Hypophysentumor bei einem Hund. Zentralbl Allg Pathol 91: 473–475
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Attia, M.A. Cytological study on pituitary adenomas in senile untreated Beagle bitches. Arch Toxicol 46, 287–293 (1980). https://doi.org/10.1007/BF00310446
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DOI: https://doi.org/10.1007/BF00310446