Abstract
Seventy F344 rats and 144 B6C3F1 mice were subdivided into seven groups. Three groups were each exposed via inhalation to 1, 5, or 25 ppm of 1,2-dibromo-3-chloropropane (DBCP) for 6 h per day, 5 days per week for 13 weeks. Three additional groups were each similarly exposed to 3, 15, or 75 ppm of 1,2-Dibromoethane (EDB). The remaining group was exposed to room air under the same conditions. At 13 weeks, rats and mice showed severe necrosis and atrophy of the olfactory epithelium in the nasal cavity after inhalation of 5 or 25 ppm DBCP and 75 ppm EDB. Lower concentrations induced squamous cell metaplasia, hyperplasia and cytomegaly of the epithelium of the respiratory nasal turbinals. Squamous metaplasia, hyperplasia and cytomegaly of the epithelium was also seen in larynx, trachea, bronchi and bronchioles. Other compound related toxic lesions in rats were seen in the liver, kidney and testes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Biava CC, Smuckler EA, Whorton D (1978) The testicular morphology of individuals exposed to dibromochloropropane. Exp Mol Pathol 29: 448–458
National Cancer Institute (1980) Inhalation bioassay of 1,2-dibromo-3-chloropropane for possible carcinogenicity, TR No. 205. US Department of Health and Humane Services, Public Health Service, National Institutes of Health, Bethesda, Maryland
National Cancer Institute (1980) Inhalation bioassay of 1,2-dibromoethane for possible carcino-genicity, TR No. 206. US Department of Health and Humane Services, Public Health Service, National Institutes of Health, Bethesda, Maryland
National Cancer Institute (1978) Bioassay of dibromochloropropane for possible carcinogenicity. US Department of Health, Education and Welfare, Technical Report Series No. 28, Public Health Service, National Institutes of Health, Bethesda, Maryland
Olson WA, Habermann RT, Weisburger EK, Ward JM, Weisburger JH (1973) Brief communication: Induction of stomach cancer in rats and mice by halogenated aliphatic fumigants. J Natl Cancer Inst 51: 1993–1995
Rowe VK, Spencer HC, McCollister DD, Hollingsworth RL, Adams EM (1952) Toxicity of ethylene dibromide determined on experimental animals. Am Med Ass Arch Ind Hyg Occup Med 6: 158–173
Ruddick JA, Newsome WH (1979) A teratogenicity and tissue distribution study on dibromochloropropane in the rat. Bull Environ Contam Toxicol 21: 483–487
Sandifer SH, Wilkins RT, Loadholt CB, Lane LG, Eldridge JC (1979) Spermatogenesis in agricultural workers exposed to dibromochloropropane (DBCP). Bull Environ Contam Toxico 23: 703–710
Short RD, Minor JL, Winston JM, Seifter J, Lee CC (1978) Inhalation of ethylene dibromide during gestation by rats and mice. Toxicol Appl Pharmacol 45: 173–182
Torkelson T, Sadek S, Rowe V, Kodama J, Anderson H, Loquvam G, Hine C (1961) Toxicologic investigations of 1,2-dibromo-3-chloropropane. Toxicol Appl Pharmacol 3: 545–559
Ward JM (1980) Unique toxic lesions induced in rodents by chemical carcinogens: indication of a short-term test for carcinogenesis bioassays. Med Hypotheses April 1980
Whorton D, Milby T, Krauss R, Stubbs H (1979) Testicular function in DBCP exposed pesticide workers. J Occup Med 21: 161–166
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Reznik, G., Stinson, S.F. & Ward, J.M. Respiratory pathology in rats and mice after inhalation of 1,2-dibromo-3-chloropropane or 1,2 dibromoethane for 13 weeks. Arch Toxicol 46, 233–240 (1980). https://doi.org/10.1007/BF00310439
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00310439