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An economical hemoperfusion system to determine in vitro clearances of various poisons with different adsorbents

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Abstract

An economical hemoperfusion system for clearance studies in vitro was developped. It was ascertained, that hemoperfusion using columns which contain 13 g of adsorbent and perfused at a blood flow rate of 1.25 ml/min results in the same relative clearances as when using clinical sized columns containing 300–355 g of the absorbent and run at 100 ml/min. The adsorption kinetics of toxicologically important drugs and pesticides are given as examples. To date 27 substances were tested systematically. The investigation has shown, that no adsorbent is without exception the best one, but the efficacy can vary from substance to substance.

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Authors and Affiliations

  1. Zentrum für Entgiftung und Giftinformation, II. Medizinische Klinik und Poliklinik der Universität, Langenbeckstrasse 1, D-6500, Mainz, Federal Republic of Germany

    S. Okonek, I. Reininghaus, H. Setyadharma & P. Gaudron

Authors
  1. S. Okonek
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  2. I. Reininghaus
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  3. H. Setyadharma
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  4. P. Gaudron
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Additional information

A preliminary report has been presented. S. Okonek, Symposion, Hemoperfusion, Kidney and Liver Support and Detoxification), Haifa, 1979

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Okonek, S., Reininghaus, I., Setyadharma, H. et al. An economical hemoperfusion system to determine in vitro clearances of various poisons with different adsorbents. Arch Toxicol 46, 215–220 (1980). https://doi.org/10.1007/BF00310437

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  • DOI: https://doi.org/10.1007/BF00310437

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