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The methenamine misunderstanding in the therapy of phosgene poisoning

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Abstract

A thorough analysis of the pertinent literature leads to the conclusion that there is no justification for the use of methenamine (hexamethylene tetramin, Urotropin) for the therapy of phosgene poisoning.

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References

  • Babad H, Zeiler AG (1973) The chemistry of phosgene. Chem Rev 73: 75–91

    Google Scholar 

  • Bickenbach O (1946) Document 1852, 3848; Office of chief of Council for War Crimes

  • Böhmer K, Hartmann A (1940) Hexamethylentetramin-Vergiftung eines Säuglings. Z Gerichtl Med 32: 381–386

    Google Scholar 

  • Cordasco EM, Stone FD (1973) Pulmonary edema of environmental origin. Chest 64: 182–285

    Google Scholar 

  • Daunderer M (1974) Akute Intoxikationen. Urban and Schwarzenberg, München Berlin Wien

    Google Scholar 

  • Daunderer M, Weger N (1975) Erste Hilfe bei Vergiftungen. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Diller WF (1974) Klinik und Pathologie der Phosgenvergiftung. Pneumologie 150: 139–148

    Google Scholar 

  • Diller WF (1978) Zur Therapie akuter Intoxikationen durch schwer wasserlösliche Lungenreizstoffe. Zbl Arbeitsmed 13: 233–236

    Google Scholar 

  • Dutch Committee for the Prevention of Accidents by Dangerous Materials. Phosgene Report of 2. 7. 1974 Ministry of Labor, Voorburg

    Google Scholar 

  • Eiden F (1961) Hexamethylentetramin. Dtsch Apoth-Z 101: 1348–1352

    Google Scholar 

  • Ehrlicher H (1972) Soforttherapie bei gewerblichen Unfällen durch chemische Arbeitsstoffe. Ärztl Praxis 24: 2136–2140

    Google Scholar 

  • Ferlinz F (1971) Lungen- und Bronchialerkrankungen. Thieme, Stuttgart

    Google Scholar 

  • Flury F, Zernik F (1931) Schädliche Gase. Springer, Berlin

    Google Scholar 

  • Fruhmann G (1974) Die Behandlung des Lungenödems nach Reizgasinhalation. Therap Gegenw 113: 38–46

    Google Scholar 

  • Foss GL, Courtice FC (1942) The use of hexamine in phosgene poisoning. Porton Report 2428

  • Frosolono MF (1977) MCA Report 08/01/76-07/01

  • Gerard RW (1948) Recent research on respiratory irritants, in Gilman: Military Medicine, vol II. Little Brown, Boston

    Google Scholar 

  • Hartung L (1892) Zur Kenntnis des Hexamethylenamins. J Prakt Chem 46: 1–20

    Google Scholar 

  • Henschler D (1963) Vergiftungen durch Kohlenoxyd, Blausäure und Reizgase. Therap Woche (Karlsruhe) 13: 382–386

    Google Scholar 

  • Karel L, Weston RE (1946) The prophylactic effect of hexamine in dogs exposed to high concentrations of phosgene. J Pharmacol Exp Ther 88: 254–259

    Google Scholar 

  • Ludewig R, Lohs K (eds) (1974) Akute Vergiftungen. Fischer, Stuttgart

    Google Scholar 

  • Moeschlin S (1980) Klinik und Therapie der Vergiftungen. Thieme, Stuttgart

    Google Scholar 

  • Moeschlin S (1965) Poisoning — diagnosis and treatment. Gruner, New York

    Google Scholar 

  • Nash T, Pattle RE (1971) The absorption of phosgene by aqueous solutions. Ann Occup Hyg 14: 227–233

    Google Scholar 

  • Nicolaier A (1894) Über die therapeutische Verwendung des Hexamethylentetramins. Zbl Med Wiss 32: 897–900

    Google Scholar 

  • Porembskij BM (1940) Über den Entgiftungsmechanismus von Hexamethylentetramin. Farmakol. Toksikol. 3: 73–75

    Google Scholar 

  • Potts AM (1945) The physiological and chemical properties of phosgene. Fasciculus on chemical warfare medicine, vol II. Washington, pp 81–147

  • Puschin NA, Mitic RV (1937) Über die Verbindungen des Phosgens mit Hexamethylentetramin. Liebigs Ann. 532: 300f

  • Ravdin IS (1942) O. E. M. cmr 13 Report, quoted from Schultz

  • Sartori M (1935) Die Chemie der Kampfstoffe. Vieweg, Braunschweig

    Google Scholar 

  • Schultz J (1945) The prophylactic action of hexamine in phosgene poisoning. Fasciculus on chemical warfare medicine, vol II Washington, p 631

  • Seidl G (1941) Methenamine effects following intraveneous injection. Zbl Chir 68: 1991

    Google Scholar 

  • Shils MB, Ginsburg TH, Bowers RV (1943) The therapeutic and prophylactic value of hexamine in phosgene poisoning. Medical Division, Edgewood Arsenal Memorandum Report 81

  • Stade K (1964) Pharmakologie und Klinik synthetischer Gifte. Berlin, Deutscher Militärverlag

    Google Scholar 

  • Stavrakis T (1971) The use of hexamethylentetramine in the treatment of phosgene poisoning. Ind Med 40: 30f

  • Thiess AM, Tress I (1975) Phosgenvergiftungen in der chemischen Industrie. Therap Woche (Karlsruhe) 41: 5889–5900

    Google Scholar 

  • Trendelenburg P (1919) Quantitative Messungen über die Spaltung des Hexamethylentetramin. Biochem Z 95: 146–163

    Google Scholar 

  • Willstätter R from Hahn O (1968) Mein Leben. Bruckmann, München

    Google Scholar 

  • Wirth W, Hecht S, Gloxhuber C (1967) Toxikologie-Fibel. Thieme, Stuttgart

    Google Scholar 

Download references

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  1. Ärztliche Abteilung der Bayer AG, D-5090, Leverkusen, Federal Republic of Germany

    Werner F. Diller

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  1. Werner F. Diller
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Diller, W.F. The methenamine misunderstanding in the therapy of phosgene poisoning. Arch Toxicol 46, 199–206 (1980). https://doi.org/10.1007/BF00310435

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  • DOI: https://doi.org/10.1007/BF00310435

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