Abstract
Dogs were given large doses of barbiturates. The effect of either haemoperfusion or haemodialysis was assessed and compared to treatment with supportive measures alone. Haemodialysis removed significant amounts of phenobarbitone, amylobarbitone and pentobarbitone, but haemoperfusion proved to be quantitatively superior both for these drugs and also for quinalbarbitone. This was also reflected by the clinical status of all three groups. Little or no disturbances in blood chemistry were observed, although platelet and leucocyte counts were diminished during haemoperfusion.
Zusammenfassung
Hunde wurden mit hohen Dosen von Barbituraten vergiftet. Die Wirkung von Hämoperfusion oder Hämodialyse wurde mit der Behandlung durch herkömmliche Methoden verglichen. Die Hämodialyse entzog bedeutende Mengen von Phenobarbiton, Amylobarbiton und Pentobarbiton, aber die Hämoperfusion erwies sich sowohl für diese Substanzen als auch für Quinalbarbiton quantitativ überlegen. Dies zeigte sich auch im klinischen Zustand aller drei Gruppen. Wenige oder keine Störungen in der Blutchemie wurden beobachtet, obwohl bei der Hämoperfusion die Anzahl von Thrombocyten und Leukocyten absank.
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Medd, R.K., Widdop, B., Braithwaite, R.A. et al. Comparison of haemoperfusion and haemodialysis in the therapy of barbiturate intoxication in dogs. Arch Toxicol 31, 163–174 (1973). https://doi.org/10.1007/BF00310394
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DOI: https://doi.org/10.1007/BF00310394