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Funktionell-morphologische Untersuchungen zur arzneimittel-induzierten Hyperphosphatasämie bei Beagle-Hunden

Functional and morphological investigations of drug-induced hyperphosphatasemia in Beagles

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Abstract

Treatment with different drugs inducing microsomal liver enzymes (clotrimazole, phenobarbital, phenylbutazone) produced an elevation of alkaline phosphatase in the plasma of Beagle dogs. It also caused an increase of the enzyme in the liver. Biochemical tests, light- and electron-microscope investigations gave no evidence of intrahepatic cholestasis, any other liver cell damage or impairment of the skeletal system. Therefore the rise of alkaline phosphatase activity was interpreted as a drug-induced increase of de-novo synthesis in the hepatocytes.

Zusammenfassung

Die Behandlung mit verschiedenen, mikrosomale Leber-enzyme induzierenden Pharmaka (Clotrimazol, Phenobarbital, Phenylbutazon) führte zu einem Aktivitätsanstieg der alkalischen Phosphatase im Blutplasma von Beagle-Hunden, der mit einer Vermehrung des Enzyms in der Leber einherging. Biochemische sowie licht- und elektronenmikroskopische Untersuchungen erbrachten keinen Hinweis auf das Vorhandensein einer intrahepatischen Cholestase, einer anderen Leberzellschädigung oder einer Beeinträchtigung des Skelettsystems. Die Aktivitätszunahme der alkalischen Phosphatase wird deshalb auf eine arzneimittelinduzierte, vermehrte de novo-Synthese in den Hepatocyten zurückgeführt.

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  1. Forschungslaboratorien der Bayer AG, Wuppertal-Elberfeld

    D. Tettenborn, G. Luckhaus & W. -H. Voigt

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  1. D. Tettenborn
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  2. G. Luckhaus
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  3. W. -H. Voigt
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Tettenborn, D., Luckhaus, G. & Voigt, W.H. Funktionell-morphologische Untersuchungen zur arzneimittel-induzierten Hyperphosphatasämie bei Beagle-Hunden. Arch Toxicol 31, 109–120 (1973). https://doi.org/10.1007/BF00310389

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  • DOI: https://doi.org/10.1007/BF00310389

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