Abstract
An unusual case of primary squamous cell carcinoma of the breast occurring after cured Hodgkin's disease is reported herein. A 27-year-old woman developed a left breast mass 2 years after chemotherapy and radiation for nodular sclerosing stage IIB Hodgkin's disease. Excisional biopsy revealed squamous cell carcinoma of the breast and a modified radical mastectomy was performed, however, no metastasis was found in the axillary nodes. She received etoposide, mitomycin-C, and doxifluoridine as adjuvant chemotherapy, and remains well without any evidence of recurrent Hodgkin's disease or breast cancer. To our knowledge, this is the first reported case of primary squamous cell carcinoma of the breast associated with Hodgkin's disease. The risk of patients treated for Hodgkin's disease developing breast cancer as a second malignant neoplasm is discussed following the report of this case.
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References
Coleman CN, Kaplan HS, Cox R, Varghese A, Butterfield P, Rosenberg SA (1982) Leukemias, non-Hodgkin's lymphomas, and solid tumours in patients treated for Hodgkin's disease. Cancer Surv 1:733–744
Nelson DF, Cooper S, Weston MG, Rubin P (1981) Second malignant neoplasms in patients treated for Hodgkin's disease with radiotherapy or radiotherapy with chemotherapy. Cancer 48:2386–2393
Zarrabi MH, Roser F (1989) Second neoplasms in Hodgkin's disease: Current controversies. Hematol Oncol Clinics of N Am 3:303–318
Tucker MA, Coleman CN, Cox RS, Varghese A, Rosenberg SA (1988) Risk of second cancers after treatment for Hodgkin's disease. N Engl J Med 14:76–81
Curtis R, Boice JD (1988) Second cancers after radiation for Hodgkin's disease. N Engl J Med 319:244–245
Janjan NA, Wilson F, Gillin M, Anderson T, Greenberg SA, Schewe K, Cox JD (1988) Mammary carcinoma developing after radiology and chemotherapy for Hodgkin's disease. Cancer 61:252–254
Carey RW, Linggood RM, Wood W, Blitzer PH (1984) Breast cancer developing in four women cured of Hodgkin's disease. Cancer 54:2234–2236
Li FP, Corkery J, Canellos G, Neitlich HW (1981) Breast cancer after Hodgkin's disease in two sisters. Cancer 47:200–202
Anderson N, Lokich J (1990) Bilateral breast cancer after cured Hodgkin's disease. Cancer 65:221–223
Boice JD, Monson RR (1977) Breast cancer in women after repeated fluoroscopic examinations of the chest. J Natl Cancer Inst 59:823–832
Tokunaga M, Land CE, Yamamoto T, Asano M, Tokuoka S, Ezaki H, Nishimori I (1987) Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950–1980. Radiat Res 112:243–272
Coleman MP, Bell CMJ, Fraser P (1987) Second primary malignancy after Hodgkin's disease, ovarian cancer and cancer of the testis: A population-based cohort study. Br J Cancer 56:349–355
Toikkanen S (1981) Primary squamous cell carcinoma of the breast. Cancer 48:1629–1632
Rostock RA, Bauer TW, Eggleston JC (1984) Primary squamous carcinoma of the breast: A review. Breast 10:27–31
Haagensen DC (1971) Diseases of the breast, 2nd edn. WB Saunders, Philadelphia, pp 600–605
Fisher ER, Gregorio RM, Palekar AS, Paulson JD (1983) Mucoepidermoid and squamous cell carcinoma of breast with reference to squamous metaplasia and giant cell tumors. Am J Surg Pathol 7:15–27
Tucker MA, Meadows AT, Boice JD, Stovall M, Oberlin O (1987) Leukemia after therapy with alkylating agents for childhood cancer. J Natl Cancer Inst 78:459–464
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Kuroi, K., Osaki, A., Yamada, H. et al. Primary squamous cell carcinoma of the breast after cured Hodgkin's disease. Surg Today 23, 81–84 (1993). https://doi.org/10.1007/BF00309006
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DOI: https://doi.org/10.1007/BF00309006