Abstract
Breast cancer is the most common malignancy in women in the UK with well-defined algorithms of management in place in the western world. Squamous cell carcinoma of the breast is a rare entity and as such knowledge about the pathophysiology, treatment and prognosis are still uncertain. The report describes an unusual case of squamous cell carcinoma arising in an area of Zuska’s disease of the breast. It illustrates the heterogeneity of the imaging findings with review of the literature. Decisions on management should be taken on an individual basis with full discussion in the multidisciplinary team meetings where all facets of the case are considered.
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References
Gupta C, Malani AK, Weigand RT, Rangineni G. Pure primary squamous cell carcinoma of the breast: a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast. Pathol Res Pract. 2006;202:465–9.
Nayak A, Wu Y, Gilcrease MZ. Primary squamous carcinoma of the breast: predictors of locoregional recurrence and overall survival. Am J Surg Pathol. 2013;37(6):867–73.
Reis-Filho JS, Lakhani SR, Gobbi H, Sniege N. Special Subtypes. In: Lakhani SR, Ellis IO, Schnitt SJ editors. WHO Classification of Tumours of the Breast. Publisher International Agency for Research on Cancer. ProQuest Ebook Central, Chapter 3. p. 49. 2013. ISBN 9789283224334. https://ebookcentral.proquest.com/lib/swansea-ebooks/detail.action?docID=4661025. Accessed 16 Nov 2017.
Cardoso F, Leal C, Meira A, Azevedo R, Mauricio MJ, Leal da Silva JM, et al. Squamous cell carcinoma of the breast. Breast. 2000;9:315–9.
Grenier J, Soria J-C, Mathieu M-C, Andre F, Abdelmoula S, Velasco V, et al. Differential immunohistochemical and biological profile of squamous carcinoma of the breast. Anticancer Res. 2007;27:547–56.
Lo G, Dessauvagie B, Sterrett G, Bourke AG. Squamous metaplasia of lactiferous ducts (SMOLD). Clin Radiol. 2012;67:e42–6.
Hennessy BT, Krishnamurthy S, Giordano S, Buchholz TA, Kau SW, Duan Z, et al. Squamous cell carcinoma of the Breast. JCI. 2006;23(21):7827–35.
Liu J, Yu Y, J-y Sun, S-s He, Wang X, Yin J, et al. Clinicopathologic characteristics and prognosis of primary squamous cell carcinoma of the breast. Breast Cancer Res Treat. 2015;149:133–40.
Grabowski J, Saltzsetin SL, Sadler G, Blair S. squamous cell carcinoma of the breast: a review of 177 cases. Am Surg. 2009;75:914–7.
Aparicio I, Martinez A, Hernandez G, Hardisson D, De Santiago J. Squamous cell carcinoma of the breast. Eur J Obstet Gynaecol. 2008;137:222–6.
Behranwala KA, Nasir N, Abdullah N, Trott PA, Gui GPH. Squamous cell carcinoma of the breast: clinico-pathologic implications and outcome. EJSO. 2003;29:386–9.
Bossuyt V, Fadare O, Martel M, Ocal IT, Burtness B, Moinfar F, et al. Remarkably high frequency of EGFR expression in breast carcinomas with squamous differentiation. Int J Surg Pathol. 2005;13(4):319–27.
Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast IV squamous cell carcinoma of ductal origin. Cancer. 1990;65:272–6.
Menes T, Schachter J, Morgenstern S, Wenig E, Lurie H, Gutman H. Primary squamous cell carcinoma (SqCC) of the breast. Am J Clin Oncol. 2003;26(6):571–3.
Vokes EE, Selwert TY. EGFR-directed treatments in SCCHN. Lancet Oncol. 2013;14(8):672–3.
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All authors have made substantial contributions to the conception and design of the case report, acquisition of data and images, drafting and revision of the article. All authors have approved the final article.
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Huws, A.M., Semkin, L., Moalla, A. et al. Primary squamous cell carcinoma of the breast in association with Zuska’s disease. Breast Cancer 25, 365–369 (2018). https://doi.org/10.1007/s12282-017-0819-3
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DOI: https://doi.org/10.1007/s12282-017-0819-3