Abstract
A 62-year-old woman with a large mass in the hepatic hilus underwent surgery. Histologically the tumor was predominantly composed of spindle-shaped cells with nuclear palisading and cells that stained positively for S-100 protein. The diagnosis was benign schwannoma (neurilemoma). The presence of lymphoid cuffing with lymphoid follicles in the capsule and xanthomatous change differed from conventional soft parts schwannoma and closely resembled benign schwannoma in the gastrointestinal tract.
Similar content being viewed by others
References
Balart LA, Hines C, Mitchell W (1983) Granular cell schwannoma of the extrahepatic biliary system. Am J Gastroenterol 78:297–300
LiVolsi VA, Perzin KH, Badder EM, Price JB, Porter M (1973) Granular cell tumors of the biliary tract. Arch Path 95:13–17
Whisnat JD, Bennet SE, Huffman SR, Weiss DL, Parker JC, Griffen WO (1974) Common bile duct obstruction by granular cell tumor (schwannoma). Am J Dig Dis 19:471–476
Izumi N, Nouchi T, Miyasawa H, Shiraki M, Senda S, Ito K, Yoshiyama N, Tonura N (1987) Nippon Naika Gakkai Zasshi (J Jpn Soc Int Med) 76:467 (Abstract in Japanese)
Nakano S, Menko S, Nomura H, Yoshinaka H, Maenohara S, Aiko T, Kaji S, Makizumi S, Sakae K (1985) Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol) 76:467 (Abstract in Japanese)
Curry B, Gray N (1972) Visceral neurofibromatosis: An unusual cause of obstructive jaundice. Br J Surg 59:494–496
Larson DM, Storsteen KA (1984) Traumatic neuroma of bile ducts with intrahepatic extension causing obstructive jaundice. Hum Path 15:287–289
Moore BW (1965) A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19:739–744
Peltonen J, Jaakkola S, Lebwohl M, Renvall S, Risteli L, Virtanen I, Vitto J (1988) Cellular differetiation and expression of matrix genes in the type 1 neurofibromatosis. Lab Invest 59:760–771
Stefansson K, Wollman RL, Moore BW (1982) S-100 protein in human chondrocytes. Nature 295:63–64
Nakajima T, Yamaguchi H, Takahashi K (1980) S-100 protein in folliculostellate cells of the rat pituitary anterior lobe. Brain Res 191:523–531
Moller M, Ingrid A, Bock E (1978) Immunohistochemical demonstration of S-100 protein and GFA protein in interstitial cells of rat pineal gland. Brain Res 140:1–13
Cocchia D, Michetti F (1981) S-100 antigen in satellite cells of the adrenal medulla and superior cervical ganglion of the rat. Cell Tissue Res 215:103–112
Nakajima T, Watanabe S, Sato Y, Kameya T, Shimosato Y, Motoi M, Lennert K (1982) S-100 protein in Langerhans cells, interdigitating reticulum cells and histiocytosis x cells. Gann 73:429–432
Takahashi K, Yamaguchi H, Ishizeki J, Nakajima T, Nakazato Y (1981) Immunohistochemical and electron microscopic localization of S-100 protein in the interdigitating reticulum cells of the lymph node. Virchows Arch [B] 37:125–135
Gaynor R, Irie R, Morton D, Herschman HR (1980) S-100 protein is present in cultured human malignant melanomas. Nature 286:400–401
Nakamura Y, Becker LE, Marks A (1983) S-100 protein in human chordoma and human and rabbit notochord. Arch Pathol Lab Med 107:118–120
Weiss SW, Langloss JM, Enzinger FM (1983) Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant schwann cell tumor. Lab Invest 49:299–308
Daimaru Y, Kido H, Hashimoto H, Enjoji M (1988) Benign schwannoma of gastrointestinal tract: A clinicopathologic and immunohistochemical study. Hum Path 19:257–264
Kido H (1986) Benign nerve sheath tumor of the stomach: A histologic and immunohistochemical analysis of 18 cases. (in Japanese with English Abstract) Fukuoka Acta Medica 77:253–263
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nagapuchi, Y., Mitsuo, H., Takeda, S. et al. Benign schwannoma in the hepatoduodenal ligament: Report of a case. Surg Today 23, 68–72 (1993). https://doi.org/10.1007/BF00309003
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00309003