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The intrinsic myenteric innervation of the hind-gut and accessory muscles of defaecation in the cat

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Summary

The anatomy and intrinsic innervation of the colon, rectum, internal anal sphincter, ano-coccygeus and recto-coccygeus have been studied in the cat with cholinesterase and catecholamine-fluorescence histochemical techniques. A variable pattern of intrinsic innervation by acetylcholinesterase-positive and adrenergic nerves along the length of the large bowel is described and is related to segmental variations in motor activity. A variation in the distribution of non-specific cholinesterase within the muscle layers is also described. Adrenergic nerves in proximal colon are arranged in the usual peri-ganglionic manner but there is also a rich direct adrenergic innervation of the longitudinal muscle in distal colon and rectum, and of circular muscle in lower rectum and internal anal sphincter. This distribution has not been reported in other species. Direct adrenergic innervation of muscle cells has been confirmed at ultrastructural level after treatment with 5-hydroxydopamine. Adrenergic neurones have not been detected in cat bowel. The ano- and recto-coccygeus muscles and internal anal sphincter possess a dense innervation of adrenergic and cholinesterase-positive nerves. It is suggested that the variation in intrinsic innervation along the large bowel should be considered in the interpretation of pharmacological and physiological experiments on this part of the gut.

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Authors and Affiliations

  1. Departments of Surgery and Oral Pathology, King's College Hospital Medical School, London

    E. R. Howard & J. R. Garrett

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  1. E. R. Howard
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  2. J. R. Garrett
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Additional information

This work was supported by a grant from the King's College Hospital Voluntary Research Trust. We wish to thank Dr. J. P. Tranzer and F. Hoffman-La Roche & Co. Ltd., Basle, for the gift of 5-hydroxydopamine.

We also thank Miss M. K. Egan and Mr. K. J. Davies for their technical assistance.

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Howard, E.R., Garrett, J.R. The intrinsic myenteric innervation of the hind-gut and accessory muscles of defaecation in the cat. Z.Zellforsch 136, 31–44 (1973). https://doi.org/10.1007/BF00307678

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  • DOI: https://doi.org/10.1007/BF00307678

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