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Über die Glia im Hypoglossuskern der Ratte nach Axotomie

Glia in the hypoglossal nucleus of the rat following axotomy

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Summary

The ultrastructure of the Nucleus hypoglossi in normal albino rats and following axotomy is described with special reference to the glia. Animals 12 to 90 days old were investigated. The following results are new: Normally in young and adult rats microglia is absent in the nucleus. Following axotomy from the 3rd day no microglia can be demonstrated in adult rats. It originates from activated and proliferated oligodendrocytes and pericyte-like cells of the vascular connective tissue. These cells surround the neurons. An activation and hypertrophy of astrocytes is visible from the 8th postoperative day on. Astrocyte processes make contacts with the perikarya and separate the microglia from the neurons. Microglia cells then show signs of degeneration. In young animals alterations following axotomy are only sparse. Already normally activated oligodendrocytes and astrocytes as well as pericyte-like connective tissue cells can be seen.

Zusammenfassung

Es wird unter besonderer Berücksichtigung der Glia über den Feinbau des Hypoglossuskerns normaler Albinoratten und nach Axotomie berichtet. Untersucht wurden Tiere vom 12.–90. Lebenstag.

Folgende Ergebnisse sind neu: Weder bei jungen noch bei erwachsenen Ratten kommt im Hypoglossuskern Mikroglia vor. Etwa ab. 3. Tag nach Axotomie kann bei erwachsenen Tieren Mikroglia nachgewiesen werden. Sie entsteht aus aktivierten und proliferierten Oligodendrocyten und pericytenähnlichen Bindegewebszellen. Die Mikroglia umhüllt die Nervenzellen. Eine Aktivierung und Hypertrophie von Astrocyten erfolgt etwa ab 8. Tag nach Axotomie. Von diesem Tage an drängen sich Astrocytenfortsätze zwischen Mikroglia und Nervenzelloberfläche. Die Mikroglia beginnt zu degenerieren. Bei Jungtieren bewirkt die Axotomie nur geringgradige Veränderungen. Schon beim Normaltier findet man aktive Oligodendroglia und Astrocyten sowie häufig pericytenähnliche Bindegewebszellen.

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  1. Anatomisches Institut der Universität Würzburg, Germany

    M. Davidoff

  2. Laboratorium für Regenerationsforschung der Bulgarischen Akademie der Wissenschaften, Sofia 31, Bulgarien

    M. Davidoff

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Herrn Prof. Schiebler zum 50. Geburtstag gewidmet.

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Davidoff, M. Über die Glia im Hypoglossuskern der Ratte nach Axotomie. Z.Zellforsch 141, 427–442 (1973). https://doi.org/10.1007/BF00307415

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