Summary
Effects of Methallibure on the gonadotropic stimulation of the regressed gonads and secondary sex characters of the pars distalis-ectomized adult green frog, Rana esculenta, were studied. Regression of the gametogenetic activity and reduction of oviducts and thumb pads are the eventual consequences of the removal of pars distalis. Homoplastic pars distalis homogenates restimulate the gametogenesis and regressed secondary sex characters due to their gonadotropic hormone contents. Methallibure in this case blocks the stimulation of these organs by homoplastic pars distalis, which indicates that this compound inhibits the action of gonadotropic hormones upon their target tissues.
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References
Basu, S. L.: Effects of testosterone and estrogen on spermatogenesis on Rana hexadactyla Lesson. J. exp. Zool. 169, 133–142 (1968).
Garbes, D. L., First, N. L.: Effects of various dose levels of ICI 33,828 on gilt ovarian function. J. Animal Sci. 28, 227–229 (1969).
Hoar, W. S., Wiebe, J., Hui Wai, E.: Inhibition of the pituitary gonadotropic activity of fishes by a dithiocarbamoylhydrazine derivative (I.C.I. 33,828). Gen. comp. Endocr. 8, 101–109 (1967).
Kanakaraj, S. R., Gangadhara, N. S.: Effect of a dithiocarbamoylhydrazine derivative (ICI 33,828) on spawning in the skipper frog, Rana cyanophlyctis Schneider. Gen. comp. Endocr. 8, 72–74 (1967).
Paget, G. E., Walpole, A. L., Richardson, D. N.: Non-steroidal inhibitors of pituitary gonadotrophic function. Nature (Lond.) 192, 1191 (1961).
Pandey, S., Leatherland, J. F.: Comparison of the effects of methallibure and thiourea on the testis, thyroid and adenohypophysis of the adult and juvenile guppy, Poecilia reticulata Peters. Canad. J. Zool. 48, 445–456 (1970).
Rastogi, R. K., Chieffi, G.: Changes in the cytology of the pars distalis of pituitary of green frog, Rana esculenta, under laboratory confinement. Gen. comp. Endocr. 15, 488–491 (1970).
Rastogi, R. K., Chieffi, G., Marmorino, C.: Effects of Methallibure (ICI 33,828) on the pars distalis of pituitary, testis and thumb pad of the green frog, Rana esculenta L. Z. Zellforsch. 123, 430–440 (1972).
Walpole, A. L.: Non-steroidal agents inhibiting pituitary gonadotrophic function. In: Biological Council Symposium on Agents Affecting Fertility (C. R. Austin and J. S. Perry, eds.), p. 159–170. London: Churchill 1965.
Wiebe, J. P.: Inhibition of pituitary gonadotropic activity in the viviparous seaperch, Cymatogaster aggregata Gibbons by a dithiocarbamoylhydrazine derivative (ICI 33,828). Canad. J. Zool. 46, 751–758 (1968).
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Work supported by the Population Council (Grants M70.082 C & M71.0132 C) of New York, and National Research Council of Italy.
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Rastogi, R.K., Chieffi, G. Inhibition of pituitary gonadotropic effects in the pars distalis-ectomized Rana esculenta by methallibure (ICI 33,828). Z. Zellforsch 129, 51–55 (1972). https://doi.org/10.1007/BF00307109
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DOI: https://doi.org/10.1007/BF00307109