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Immunhistochemische Studien an normaler und pathologischer Magenschleimhaut: Nachweis fetaler und magenschleimhautspezifischer Antigene

Immunohistochemical studies on non neoplastic and neoplastic gastric mucosa. Determination of embryonic and specific antigens

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Summary

The distributions of acid alpha1-glycoprotein, alpha1-fetoprotein, beta-galactosidase and gastrin in gastric carcinoma and gastric ulcer as well as in the neighbourhood of these lesions were studied by means of immunohistochemical methods on imprint preparation. We could not find significant differences between gastric carcinoma and the nonneoplastic lesions, except for the acid alpha1-glycoprotein.

The results of this first study indicate that the immunochemical and immunohistological assay of acid alpha1-glycoprotein might be of practical value in diagnosing malignant changes of gastric mucosa.

Zusammenfassung

Mit immunfluoreszenzmikroskopischen Methoden wurde die Verteilung von α 1-Fetoprotein, α 1-Glykoprotein, Magenschleimhautantigen sowie Gastrin und β-Galactosidase im Magencarcinom, bei Ulcus ventriculi, sowie in der näheren und weiteren Umgebung des Carcinoms und in der Ulcusnachbarschaft untersucht. Dabei findet sich kein signifikanter Unterschied zwischen Carcinom und nicht neoplastisch erkranktem Magen, mit Ausnahme des sauren α 1-Glycoproteins. Dies scheint darauf hinzudeuten, daß der Nachweis dieser Substanz in hohem Ausmaß für neoplastisches Wachstum im Magen typisch ist.

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Authors and Affiliations

  1. Chirurgische Universitätsklinik Innsbruck, Österreich, Germany

    N. Falser, B. Lederer, K. Schwamberger & H. Reissigl

  2. Gastro-enterologisches Laboratorium, Österreich, Germany

    N. Falser, B. Lederer, K. Schwamberger & H. Reissigl

  3. Pathologisch-anatomisches Institut der Universität Innsbruck, Österreich, Germany

    N. Falser, B. Lederer, K. Schwamberger & H. Reissigl

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  1. N. Falser
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  2. B. Lederer
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  3. K. Schwamberger
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  4. H. Reissigl
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Mit freundlicher Unterstützung des Fonds zur Förderung der Wissenschaftlichen For schung in Österreich.

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Falser, N., Lederer, B., Schwamberger, K. et al. Immunhistochemische Studien an normaler und pathologischer Magenschleimhaut: Nachweis fetaler und magenschleimhautspezifischer Antigene. Z. Krebsforsch. 84, 19–24 (1975). https://doi.org/10.1007/BF00305685

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  • DOI: https://doi.org/10.1007/BF00305685

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