Abstract
Eighty children who in the first 2 years of life had signs and symptoms relating to a cerebral neoplasm were studied over an 18-year period (1970–1987), the mean follow-up being 8.2 years. In each case age at onset, clinical presentation, tumor location and pathological diagnosis, extent of surgical resection, postoperative mortality, adjuvant therapy length of survival and quality of life were assessed. Supratentorial tumors (59%) were more common than infratentorial. The most frequent clinical presenting feature (70%) was increased intracranial pressure. Sixty-three patients (79%) were operated on and in all of these cases a histological diagnosis was obtained. Astrocytomas (41%) and medulloblastomas (20%) were the most common oncotypes. Surgical mortality was 17.4% and the 5-year survival rate was 54%. Quality of life was assessed for all long-term surviving patients using a specifically designed protocol. Normal physical and intellectual performances were found in 46% of cases, and all together 75% of the patients had sufficient autonomy in daily life. The prognosis is more closely related to tumor location and type of treatment than to histological diagnosis or age at onset.
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References
Araki C, Matsumoto S (1969) Statistical reevaluation of pinealoma and related tumors in Japan. J Neurosurg 30: 146–149
Balestrini MR, Zanette M, Micheli R, Fornari M, Solero CL, Broggi G (1990) Hemispheric cerebral tumors in children. Long-term prognosis concerning survival rate and quality of life—considerations on a series of 64 cases operated upon. Child's Nerv Syst 6: 143–147
Cheng MK (1982) Brain tumors in the People's Republic of China: a statistical review. Neurosurgery 10: 16–21
Cohen ME, Duffner PK (1984) Brain tumors in children. Principles of diagnosis and treatment. Raven Press, New York
Colangelo M, Buonaguro A, Ambrosio A (1980) Intracranial tumors in early infancy. J Neurosurg Sci 24: 27–32
D'Angelo A, Micheli R, Balestrini MR (1990) Clinica dei tumori cerebrali. Diagnosi e prognosi: generalità. Second continued education course: I Tumori Cerebrali del Bambino, Milan, 6–9 March 1990
Di Rocco C (1989) Trattamento chirurgico dei tumori sovratentoriali della linea mediana. Proceedings of the congress: Patologie del Sistema Nervoso Cerebrale del Bambino-Aspetti Medici e Chirurgici, Santa Margherita Ligure, 22–24 June 1989
Duffner PK (1990) Long term effects of central nervous system treatment on children with brain tumors. Second continued education course: I Tumori Cerebrali del Bambino, Milan, 6–9 March 1990
Duffner PK, Cohen ME, Thomas P (1983) Late effects of treatment on the intelligence of children with posterior fossa tumors. Cancer 51: 233–237
Duffner PK, Cohen ME, Myers MH, Heisa HW (1986) Survival of children with brain tumors: SEER program, 1973–1980. Neurology 36: 597–601
Ellams ID, Neuhauser G, Agnoli AL (1986) Congenital intracranial neoplasms. Child's Nerv Syst 2: 165–168
Farwell JR, Dohrmann GY, Flannery JT (1978) Intracranial neoplasms in infants. Arch Neurol 35: 533–537
Fessard C (1968) Congenital tumors in infancy: 66 clinicoanatomical case studies. Am J Dis Child 115: 302–308
Galassi E, Godano U, Cavallo M, Donati R, Nasi MT (1989) Intracranial tumors during the 1st year of life. Child's Nerv Syst 5: 288–298
Gjerris F (1976) Clinical aspects and long-term prognosis of intracranial tumours in infancy and childhood. Dev Med Child Neurol 18: 145–159
Katsura S, Suzuki J, Wada T (1959) A statistical study of brain tumors in the neurosurgical clinics in Japan. J Neurosurg 16: 570–580
Koos WT, Miller MH (1971) Intracranial tumors of infants and children. Thieme, Stuttgart
Kumar R, Jonas RAC, Tekkok IH (1990) Has modern management improved the outcome of infants with intracranial tumors? Child's Nerv Syst 6: 327–330
Kumar R, Tekkok IH, Jones RAC (1990) Intracranial tumors in the first 18 months of life. Child's Nerv Syst 6: 371–374
Isaacs H (1985) Perinatal (congenital and neonatal) neoplasms: a report of 110 cases. Pediatr Pathol 3: 165–216
Jellinger K, Sunder-Plassmann M (1973) Connatal intracranial tumors. Neuropediatrie 4: 46–63
Jooma R, Hayward RD, Grand DN (1984) Intracranial neoplasms during the first year of life: analysis of one hundred consecutive cases. Neurosurgery 14: 31–41
Jooma R, Kendall BE, Hayward RD (1984) Intracranial tumors in neonates: a report of seventeen cases. Surg Neurol 21: 165–170
Lapras C, Guildburd JN, Guyotal J, Patet JD (1988) Brain tumors in infants: a study of 76 patients operated upon. Child's Nerv Syst 4: 100–103
Locatelli D, Bonfanti N, Sfogliarini R, Pezzotta S (1987) Tumori cerebrali nel primo anno di vita. In: Paoletti P (ed) Attualità in neurochirurgia. Monduzzi, Bologna, pp 347–352
Mori K, Kurisaka M (1986) Brain tumors in childhood: statistical analysis of cases from the brain tumor registry in Japan. Child's Nerv Syst 2: 233–237
Oi S, Kokunai T, Matsumoto S (1990) Congenital brain tumors in Japan (ISPN cooperative study): specific clinical features in neonates. Child's Nerv Syst 6: 86–91
Oi S, Matsumoto S, Choi JU, Kang JK, Wong T, Wang C, Chan TST (1990) Brain tumors diagnosed in the first year of life in five Far-Eastern countries: statistical analysis of 307 cases. Child's Nerv Syst 6: 79–85
Raimondi AJ, Tomita T (1983) Brain tumors during the first year of life. Child's Nerv Syst 10: 193–207
Sakamoto K, Kobayashi N, Otsubo H, Tanaka Y (1986) Intracranial tumors in the first year of life. Child's Nerv Syst 2: 126–129
Sano K (1987) A statistical study of brain tumors in Japan: general features. Jpn J Clin Oncol 17: 19–28
Sato O, Tamura A, Sano K (1975) Brain tumors of early infants. Child's Brain 1: 121–125
Schiffer D (1989) Patoloiia dei tumori del sistema nervoso centrale e suoi correlati. Proceedings of the congress: Patologie del Sistema Nervoso Centrale de Bambino—Aspetti Medici chirurgici, Santa Margherita Ligure, 22–24 June 1989
Solitare GB, Krigman MR (1964) Congenital intracranial neoplasms? J Neuropathol Exp Neurol 2: 280–292
Spunberg JJ, Chang CH, Goldman M (1981) Quality of long-term survival following irradiation for intracranial tumors in children under the age for two. Int J Radiat Oncol Biol Phys 7: 727–736
Tomita T, McLone DG (1985) Brain tumors during the first twenty-four months of life. Neurosurgery 17: 913–919
Wakai S, Arai T, Nagai M (1984) Congenital brain tumors. Surg Neurol 21: 597–609
Zuccaro G, Taraturo AL, Monges J (1986) Intracranial neoplasms during the first year of life. Surg Neurol 26: 29–36
Zuelch KJ (1963) Grading of malignancy of brain tumors. Acta Neurochir (Wien) Suppl 10: 117–119
Zuelch KJ (1974) Tumori cerebrali: biologia epatologia. Piccin, Padua, pp 55–81
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Balestrini, M.R., Micheli, R., Giordano, L. et al. Brain tumors with symptomatic onset in the first two years of life. Child's Nerv Syst 10, 104–110 (1994). https://doi.org/10.1007/BF00302773
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DOI: https://doi.org/10.1007/BF00302773