Abstract
The production of antibodies to IgG and type II collagen occurs in a similar fashion in human rheumatoid arthritis and adjuvant arthritis. In this study, the effect of dexamethasone (DXT) and acetylsalicylic acid (ASA) on antibody synthesis was analysed. Daily treatment with DXT (0.3 mg/kg per day p.o.) or with ASA (200 mg/kg per day p.o.) from day 14 to day 56 after arthritis induction inhibited both the synthesis of antibodies to IgG and type II collagen and also the humoral immune response to the mycobacteria that induced the disease. The immunosuppressive response was similar for both drugs: DXT, which is known to suppress the immune response, and ASA, a classical anti-inflammatory agent.
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Waksman BH, Pearson CM, Sharp JT (1960) Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen. J Exp Med 85:403–417
Quagliata F, Sanders PM, Gardner DL (1969) Suppression of adjuvant arthritis by a new cytotoxic compound, rubidomycin. Ann Rheum Dis 28:163–171
Franch A, Cassany S, Castellote C, Castell M (1992) Adjuvant arthritis pretreatment with type II collagen and Mycobacterium butyricum. Immunobiology 186:351–361
Holoshitz J, Naparstek Y, Ben-Nun A, Cohen IR (1983) Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science 219:56–58
Taurog JD, Sandberg GP, Mahowald ML (1983) The cellular basis of adjuvant arthritis. II. Characterization of the cells mediating passive transfer. Cell Immunol 80:198–204
Holoshitz J, Matitiau A, Cohen IR (1984) Arthritis induced in rats by clones of T lymphocytes responsive to mycobacteria but not collagen type II. J Clin Invest 73:211–215
Franch A, Castellote C, Vilà JLL, Vilaró S, Castell M (1994) Anti-cytoskeletal autoantibody development in adjuvant arthritis. J Rheumatol 21:489–497
Castell M, Castellote C, Queralt J, Barberá G, Torralba A (1985) Evidence of autoantibodies in rats with adjuvant-induced arthritis. Allergol Immunopathol 13:399–403
Castell M, Castellote C, Queralt J (1986) Anti-immunoglobulin antibody detection in adjuvant arthritis by an ELISA technique. Pathol Res Pract 181:664–667
Franch A, Cassany S, Castellote C, Castell M (1994) Time course of antibodies against IgG and type II collagen in adjuvant arthritis. Role of mycobacteria administration in antibody production. Immunobiology 190:93–104
Billingham MEJ (1990) Models of arthritis and the search for anti-arthritic drugs. In: Orme MCLE (ed) Anti-rheumatic drugs. Pergamon Press, New York, pp 1–47
Phadke K, Carroll J, Nanda S (1982) Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats. Clin Exp Immunol 47:579–586
Yamaki K, Nakagawa H, Tsurufuji S (1987) Inhibitory effects of anti-inflammatory drugs on type II collagen induced arthritis in rats. Ann Rheum Dis 46:543–548
Cassany S, Franch A, Castell M, Castellote C, Queralt J (1990) Analisis directo per ordenador de los datos obtenidos por ELISA en la cuantificación de anticuerpos. Inmunología 9:91–98
Guttman I (1982) Linear models: an introduction. Wiley, New York
Taurog JD, Argentieri DC, McReynolds RA (1988) Adjuvant arthritis. Methods Enzymol 162:339–355
Brahn E (1991) Animal models of rheumatoid arthritis. Clues to etiology and treatment. Clin Orthop 265:42–53
Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231:232–235
Baker DG, Rabinowitz JL (1986) Current concepts in the treatment of rheumatoid arthritis. J Clin Pharmacol 26:2–21
Flower RJ (1985) Background and discovery of lipocortins. Agents Actions 17:255–262
Jonat C, Rahmsdorf HJ, Park K-K, Cato ACB, Gebel S, Ponta H, Herrlich P (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189–1204
Besedovsky H, DelRay A, Sorkin E, Dinarello CA (1986) Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233:652–654
DiMartino MJ, Lee JC, Badger AM, Muirhead KA, Mirabelli CK, Hanna N (1986) Antiarthritic and immunoregulatory activity of spirogermanium. J Pharmacol Exp Ther 236:103–110
Johnson WJ, Muirhead KA, Meunier PC, Votta BJ, Schmitt JC, DiMartino MJ, Hanna N (1986) Macrophage activation in rat models of inflammation and arthritis. Arthritis Rheum 29:1122–1130
Conolly KM, Stecher VJ, LaBrie T, Fluno C (1988) Modulation of the acute phase response and in vitro measurement of interleukin-1 activity following administration of dexamethasone to adjuvant-arthritis rats. Immunopharmacology 15:133–142
Goodwin JS (1984) Immunologic effects of nonsteroidal antiinflammatory drugs. Am J Med 15:7–15
Goodwin JS, Ceuppens JL (1983) Regulation of the immune response by prostaglandins. J Clin Immunol 3:295–315
Cortet B, Duquesnoy B (1991) Action des anti-inflammatoires non stéroïdiens sur le système immunitaire. Rev Rhum 58:379–386
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Castellote, C., Castell, M. & Franch, A. Effect of acetylsalicylic acid and dexamethasone on antibody production in adjuvant arthritis. Rheumatol Int 14, 27–31 (1994). https://doi.org/10.1007/BF00302668
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DOI: https://doi.org/10.1007/BF00302668