Abstract
In order to investigate the frequency of congenital hypertrophy of the retinal pigment epithelium (CHRPE) in sporadic colorectal cancer, ophthalmoscopy was carried out in 34 patients with colorectal carcinoma without known familial disposition. CHRPE is one of the most frequent extracolonic manifestations in familial adenomatous polyposis. None of the patients showed any sign of CHRPE. It is concluded that although genetic factors are presumably of importance in the development of sporadic colorectal cancer, CHRPE cannot be used as a marker for future risk of colorectal carcinoma except in polyposis families.
Résumé
Afin de déterminer la fréquence d'une hypertrophie congénitale de l'épithélium pigmentaire de la rétine (CHRPE) en cas de cancer colo-rectal sporadique, un examen ophtalmoscopique a été chez 34 patients porteurs d'un cancer colo-rectal sans prédisposition familiale connue. Le CHRPE est une des manifestations extra-coliques la plus fréquente en cas de polypose adénomateuse familiale. Aucun des patients n'a montré de signes de CHRPE. On en conclut que, bien que des facteurs génétiques puissent constituer un élément important dans le développement du cancer colo-rectal sporadique, le CHRPE ne peut pas étre utilisé comme un marqueur en faveur d'un risque futur de cancers colo-rectaux à l'exception de ceux survenant en cas de polypose familiale.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Søndergaard JO, Bülow S, Lynge E (1991) Cancer incidence among parents of patients with colorectal cancer. Int J Cancer 47:202–206
Ponz de Leon M, Sassatelli R, Sacchetti C, Zanghieri G, Scalmati A, Roncucci L (1989) Familial aggregation of tumors in the three-year experience of a population based colorectal cancer registry. Cancer Research 49:4344–4348
Bülow S, Søndergaard JO, Witt IN, Larsen E, Tetens G (1984) Mandibular osteomas in familial polyposis coli. Dis Colon Rectum 27:105–108
Utsunomiya J, Nakamura T (1975) The occult osteomatous changes in the mandible in patients with familial polyposis coli. Br J Surg 62:45–51
Søndergaard JO, Svendsen LB, Witt IN, Bülow S, Lauritzen KB, Tetens G (1985) Mandibular osteomas in colorectal cancer. Scand J Gastroenterol 20:759–761
Berk T, Cohen Z, Mcleod RS, Parker JA (1988) Congenital hypertrophy of the retinal pigment epithelium as a marker for familial adenomatous polyposis. Dis Colon Rectum 31:253–257
Traboulsi EI, Krush AJ, Gardner EJ, Booker SV, Offerhaus GJA, Yardley JH, Hamilton SR, Luk GD, Giardiello FM, Welsh SB, Hughes JP, Maumenee IH (1987) Prevalence and importance of pigmented ocular fundus lesions in Gardner's syndrome. N Engl J Med 316:661–667
Blaire NP, Trempe CL (1980) Hypertrophy of the retinal pigment epithelium associated with Gardner's syndrome. Am J Ophthalmol 90:661–667
Lyons LA, Lewis RA, Strong LC, Zukerbrod S, Ferell RE (1988) A genetic study of Gardner's syndrome and congenital hypertrophy of the retinal pigment epithelium. Am J Hum Genetics 42:290–296
Lewis RA, Crowder WE, Eierman LA, Nussbaum RL, Ferrell RE (1984) The Gardner Syndrome. Significance of ocular features. Ophthalmol 91:916–924
Baba S, Tsuchiya M, Watanabe I, Machida H (1990) Importance of retinal pigmentation as a subclinical marker in familial adenomatous polyposis. Dis Colon Rectum 33:660–665
Mellergaard A, Jensen OM, Lynge E (1989) Cancer incidence among spouses to patients with colorectal cancer. Int J Cancer 44:225–228
Olschwang S, Tiret A, Laurent Puig P, Muleris M, Parc R, Thomas G (1993) Restiction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients. Cell 75:959–968
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hartvigsen, A., Myrhøj, T., Bülow, S. et al. Ophthalmoscopy for congenital hypertrophy of the retinal pigment epithelium (CHRPE) in patients with sporadic colorectal carcinoma. Int J Colorect Dis 10, 138–139 (1995). https://doi.org/10.1007/BF00298534
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00298534