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A case of fatal poisoning by Gyromitra esculenta

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Abstract

A case of fatal poisoning by the mushroom Gyromitra esculenta (false morel) in a 53-year-old woman is reported. Clinical data were characterized initially by vomiting and diarrhea, and subsequently by hypotension, anuria, jaundice, hemiplegia, and coma. Death followed on the 3rd day. Prominent pathologic findings were brain edema, necrosis, fatty degeneration of the liver, nephrosis, scattered petechiae, and small hemorrhages. Gyromitrin was extracted in methanol, purified by thin layer chromatography, identified by I. R. spectrometry, and weighed. The relationship between O. D. at 277 mμ and the concentration (0.1–0.5mg/ml in absolute ethyl alcohol) was established.

Zusammenfasssung

Es wird ein tödlicher Vergiftungsfall mit Gyromitra esculenta (Frühjahrslorchel) bei einer 53-jährigen Frau beschrieben. Initial kam es zu Erbrechen und Durchfall, danach zu Blutdrucksenkung, Anurie, Ikterus, Hemiplegie und Koma. Der Tod trat am 3. Tage ein. Der pathologische Befund zeigte Hirnödem, Nekrosen und fettige Degeneration der Leber, Nephrose sowie Petechien und Hämorrhagien. Gyromitrin wurde in Methanol extrahiert, dünnschichtchromatographisch gereinigt, mittels IR-Spektrometrie identifiziert und gewogen. Die Relationen zwischen Absorptions-Werten bei 277 mμ Wellenlänge und Konzentration (0.1–0.5 mg/ml in reinem Äthanol) werden angegeben.

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Giusti, G.V., Carnevale, A. A case of fatal poisoning by Gyromitra esculenta . Arch. Toxicol. 33, 49–54 (1974). https://doi.org/10.1007/BF00297052

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