Abstract
The production of progesterone metabolites by rat liver microsomes from TAO-treated rats was investigated. More than ten metabolites could be identified, including various dihydroxy-progesterones. CCl4 co-incubation modifies the P-450-dependent progesterone metabolite profile in a remarkable fashion without production of CCl4 progesterone adducts.
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Dedicated to Professor Dr. med. Herbert Remmer on the occasion of his 65th birthday
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Larroque, C., Lange, R. Interaction of carbon tetrachloride and progesterone metabolism in liver microsomes from triacetyloleandomycin-treated rats. Arch Toxicol 60, 122–123 (1987). https://doi.org/10.1007/BF00296963
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DOI: https://doi.org/10.1007/BF00296963