Abstract
Liver function in patients with liver disease can be estimated by caffeine clearance. Our data, however, demonstrate the additional influence of factors other than liver disease on the caffeine test. Smoking enhances caffeine clearance in both healthy volunteers and patients with severe hepatic disorders, whereas co-medication with mexiletine strongly inhibits caffeine elimination.
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Dedicated to Professor Dr. med. Herbert Remmer on the occasion of his 65th birthday
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Joeres, R., Klinker, H., Heusler, H. et al. Factors influencing the caffeine test for cytochrome P 448-dependent liver function. Arch Toxicol 60, 93–94 (1987). https://doi.org/10.1007/BF00296957
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DOI: https://doi.org/10.1007/BF00296957