Summary
Serum intact parathyroid hormone (PTH), 25 hydroxyvitamin D(25OHD), 1,25 dihydroxyvitamin D (1,25(OH)2D), albumin, and ionized calcium were measured in 61 Chinese female patients with hip fracture and 61 control subjects. Hip fracture patients had low albumin, ionized calcium, and 250HD levels. Serum PTH and 1,25 (OH)2D values were not different between the two groups. We conclude that although 250HD level in hip fracture patients is low, there is no evidence of secondary hyperparathyroidism, suggesting that the low 250HD levels may be a secondary phenomenon in response to the fracture.
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Lau EMC, Cooper C, Barker DJP, Donnan SPB (1990) Incidence and risk factors for hip fracture in Hong Kong Chinese, vol 1. In: Christiansen C, Ovengaard K, (eds) Proc of 3rd Intl Symp on Osteoporosis, October 14–20, 1990, Copenhagen. Denmark
Boyce WJ, Vessey MP (1985) Rising incidence of fracture of the proximal femur. Lancet i:150–151
Baker MR, McDonnell H, Peacock M, Nordin BEC (1979) Plasma 25-hydroxy-vitamin D concentration in patients with fracture of the femoral neck. Br Med J 1:589
Weisman Y, Schen RJ, Eisenberg Z, Edelstein S, Harell A (1981) Inadequate status and impaired metabolism of vitamin D in the elderly. Isr J Med Sci 17:17–21
Toss G, Almqvist S, Larsson L, Zetherquist H (1980) Vitamin D deficiency in a welfare institution for the aged. Acta Med Scand 208:87–89
Lau EMC, Woo J, Swaminathan R, MacDonald D, Donnan SPB (1989) Plasma 25-hydroxyvitamin D concentration in patients with hip fracture in Hong Kong. Gerontology 35:198–204
Pun KK, Wong FH, Wang C, Lau P, Pun WK, Chow SP, Cheng CL, Leong JC, Young RT (1990) Vitamin D status among patients with fractured neck of femur in Hong Kong. Bone 11:305–308
Compston JE, Silver AC, Croucher PI, Brown RC, Woodhead JS (1989) Elevated serum intact parathyroid hormone levels in elderly patients with hip fracture. Clin Endocrinol 31:667–672
Young G, Marcus R, Minkoff JR, Lein L, Segre GV (1987) Age-related rise in parathyroid hormone in man: the use of intact and mid-molecule antisera to distinguish hormone secretion from retention. J Bone Miner Res 2:367–374
Sherman SS, Hollis Bere, Tobin JD (1990) Vitamin D status and related parameters in a healthy population. The effects of age, sex and season. J Clin Endocrinol Metab 71:405–413
Chan E, Lau E, Shek CC, MacDonald D, Woo J, Leung PC, Swaminathan R (1992) Age-related changes in bone density, serum parathyroid hormone, calcium absorption and other indices of bone metabolism in Chinese women. Clin Endocrinology 36:375–61
Ho SC, Donnan SPB, Sham A (1988) Dietary intake among elderly Chinese in Hong Kong. J Hum Nutr Diet 1:205–215
Lau EMC, Leung PC, Woo J, Swaminathan R (1990) The determinants of bone density in elderly Chinese women. J Clin Exper Gerontol 12:137–155
Lau EMC, Donnan S, Barker D, Cooper C (1988) Physical activity and calcium intake in fracture of the proximal femur in Hong Kong. Br Med J 297:1441–1443
Payne RB, Little AJ, William RB, Milner JR (1973) Interpretation of serum calcium in patients with abnormal protein. Mr Med J iv:643–646
MacDonald D, Swaminathan R (1988) Seasonal variation in 25-hydroxyvitamin D concentration in plasma of Hong Kong Chinese. Clin Chem 34:2375
Cooper C, McLaren M, Wood PJ, Coulton L, Kanis JA (1989) Indices of calcium metabolism in women with hip fractures. Bone Miner 5:193–200
Lips P, Netelembos JC, Jongen MJM, van Ginkel FC, Althuis AC, van Schaik CL, van der Vijgh WJF, Vermeiden JPW, van der Mee C (1982) Histomorphometric profile and vitamin D status in patients with femoral neck fracture. Metab Bone Dis Rel Res 4:5–93
Fleck A, Raines G, Hawker F, Trotter J, Wallace PI, Ledingham I McA, Calman KC (1985) Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury. Lancet 1:781–784
Hoikka V, Alhava EM, Savolainer K, Parvianen M (1982) Osteomalacia in fracture of the proximal femur. Acta Orthop Scand 53:255–260
Lips P, Bouillon R, Jongen MJ, van Gintzel FC, van der Vijgh WJ, Netelenbos JC (1985) The effect of trauma on serum concentrations of vitamin D metabolites in patients with hip fracture. Bone 6:63–67
Hartwell D, Ries BJ, Christiansen C, Thomas K, Johansen JS, Ralorop (1987) Bone metabolism and bone status in osteoporotic patients. Acta Med Scand 222:453–458
Lund B, Sorensen OH, Christensen AB (1975) 25-hydroxycholecalciferol and fractures of the proximal femur. Lancet ii:300–302
Hordon LD, Peacock M (1987) Vitamin D metabolism in women with femoral neck fracture. Bone Miner 2:413–426
Eventon I, Frisch B, Alk D, Eisenberg Z, Weisman Y (1989) Bone biopsies and serum vitamin D levels in patients with hip fracture. Acta Orthop Scand 60:411–413
Stevenson JC, Allen PR, Abeyasekera A, Hill PA (1987) Osteoporosis with hip fracture: changes in calcium regulating hormones. Eur J Clin Invest 76:357–360
Nilsson BE, Westlin NE (1972) The plasma concentration of alkaline phosphatase, phosphorus and calcium following femoral neck fracture. Acta Orthop Scand 43:504–510
Lal SK, Jacob KC, Nagi ON, Annamalai AL, Nain CR (1976) Variation of some plasma components after closed fracture. J Trauma 16:206–211
Woo J, Swaminathan R, Pang CP, MacDonald D, Mak YT, Ho SC, Lau E (1989) Some biochemical indices of bone turnover in elderly Chinese. J Med 20:229–239
Woo J, Swaminathan R, Pang CP, Mak YT, MacDonald D (1990) A comparison of biochemical indices of bone turnover in elderly institutionalized and free-living subjects. Bone Miner 8:31–38
Woo J, Lau E, Swaminathan R, Pang CP, MacDonald D (1990) Biochemical predictors for osteoporotic fracture in elderly Chinese—a longitudinal study. Gerontology 36:55–58
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MacDonald, D., Lau, E., Chan, E.L.P. et al. Serum intact parathyroid hormone levels in elderly Chinese females with hip fracture. Calcif Tissue Int 51, 412–414 (1992). https://doi.org/10.1007/BF00296672
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DOI: https://doi.org/10.1007/BF00296672