Abstract
In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to “focal cortical dysplasia” in 6 patients and to “microdysgenesis” in 5 others. This study focuses on the various neuropathological presentations of these malformative epileptogenic lesions, and on correlations with neuro-imaging data.
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References
Bruton CJ (1988) The neuropathology of temporal lobe epilepsy. Maudsley Monographs No. 31, Oxford University Press, Oxford
Daumas-Duport C, Scheithauer BW, Chodkiewicz JP, Laws ER, Vedrenne C (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of 39 cases. Neurosurgery 23: 545–556
De Rosa MJ, Farrell MA, Burke MM, Secor DL, Vinters HV (1992) An assessment of the proliferative potential of “balloon cells” in focal cortical resections performed for childhood epilepsy. Neuropathol Appl Neurobiol 18: 566–574
Farrell MA, De Rosa MJ, Curran JG, Lenard Secor D, Cornford ME, Comair YG, Peacock WJ, Shields WD, Vinters HV (1992) Neuropathologic findings in cortical resections (including hemispherectomies) performed for the treatment of intractable childhood epilepsy. Acta Neuropathol 83: 246–259
Ferrer I, Pineda M, Tallada M, Oliver B, Russi A, Oller L, Noboa R, Zujar MJ, Alcantara S (1992) Abnormal localcircuit neurons in epilepsia partialis continua associated with focal cortical dysplasia. Acta Neuropathol 83: 647–652
Hardiman O, Burke T, Phillips J, Murphy S, O'Moore B, Staunton H, Farrell MA (1988) Microdysgenesis in resected temporal neocortex: incidence and clinical significance in focal epilepsy. Neurology 38: 1041–1047
Jellinger K (1987) Neuropathological aspects of infantile spasms. Brain Dev 9: 349–357
Lyon G, Gastaut H (1985) Considerations on the significance attributed to unusual cerebral histological findings recently described in eight patients with primary generalized epilepsy. Epilepsia 26: 365–367
Manz HJ, Phillips TM, Rowden G, McCullough DC (1979) Unilateral megalencephaly, cerebral cortical dysplasia, neuronal hypertrophy, and heterotopia: cytomorphometric, fluorometric cytochemical, and biochemical analyses. Acta Neuropathol (Berl) 45: 97–103
Marchal G, Andermann F, Tampieri D, Robitaille Y, Melanson D, Sinclair B, Olivier A, Silver K, Langevin P (1989) Generalized cortical dysplasia manifested by diffusely thick cerebral cortex. Arch Neurol 46: 430–434
Meencke HJ, Janz D (1985) The significance of microdysgenesia in primary generalized epilepsy: an answer to the considerations of Lyon and Gastaut. Epilepsia 26: 368–371
Palmini A, Andermann F, Olivier A, Tampieri D, Robitaille Y, Andermann E, Wright G (1991) Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. Ann Neurol 30: 741–749
Robain O, Floquet C, Heldt N, Rozenberg F (1988) Hemimegalencephaly: a clinicopathological study of four cases. Neuropathol Appl Neurobiol 14: 125–135
Robain O, Chiron C, Dulac O (1989) Electron microscopic and Golgi study in a case of hemimegalencephaly. Acta Neuropathol 77: 664–666
Rubinstein LJ (1972) Tumours of the central nervous system. In: Rubinstein LJ (ed) Atlas of tumour pathology, 2nd series, vol 6. American Armed Forces Institute of Pathology, Washington D.C.
Taylor DC, Falconer MA, Bruton CJ, Corsellis JAN (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34: 369–387
Townsend JJ, Nielsen SL, Malamud N (1975) Unilateral megalencephaly: hamartoma or neoplasm? Neurology 25: 448–453
Vinters HV, Fisher RS, Cornford ME, Peacock WJ, Shields WD (1990) Neuropathologic substrates of infantile spasms: a study based on surgically resected cerebral cortical tissue. Epilepsia 31: 652
Vinters HV, Fisher RS, Orloff F, Peacock W, Shields WD (1990) Cerebral cortical dysplasia and hamartomas in pediatric epilepsy: immunohistochemical study. J Neuropathol Exp Neurol 49: 305
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Vital, A., Marchal, C., Loiseau, H. et al. Glial and neuronoglial malformative lesions associated with medically intractable epilepsy. Acta Neuropathol 87, 196–201 (1994). https://doi.org/10.1007/BF00296190
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DOI: https://doi.org/10.1007/BF00296190