Summary
A multicenter, longitudinal study of children below the age of 16 years with newly diagnosed Type 1 (insulin-dependent) diabetes treated either with porcine monocomponent insulin (n=26) or semisynthetic human monocomponent insulin (n=26) was performed during the first 24 months after onset of diabetes. The two groups were carefully matched for age, duration of disease symptoms, initial metabolic values, islet cell antibodies and HLA-DR antigens. During the 24-month observation period there was no significant difference between the two groups in respect to the clinical course, insulin dosage, HbA1 and residual B-cell activity. No child in either group had a real remission without necessitating insulin therapy. The prevalence of insulin antibodies increased slowly and was 62% in the group treated by human insulin and 52% in the porcine insulin-treated group after 24 months. The titres were generally low and there was no statistical difference between the two groups in respect to insulin antibody formation.
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Owens DR, Jones MK, Hayes TM, Heding LG, Alberti KGMM, Home PD, Burrin JM, Newcombe RG (1981) Human insulin: study of safety and efficacy in man. Br Med J 282: 1264–1266
Greene SA, Smith MA, Cartwright B, Baum JD (1983) Comparison of human versus porcine insulin in treatment of diabetes in children. Br Med J 287: 1578–1579
Mann NP, Johnston DI, Reeves WG, Murphy MA (1983) Human insulin and porcine insulin in the treatment of diabetic children: comparison of metabolic control and insulin antibody production. Br Med J 287: 1580–1582
Schernthaner G, Borkenstein M, Fink M, Mayr WR, Menzel J, Schober E (1983) Immunogenicity of human insulin (Novo) or pork monocomponent insulin in HLA-DR-typed insulin-dependent diabetic individuals. Diabetes Care 6 [Suppl 1]: 43–48
Sonnenberg GE, Berger M (1983) Human insulin: Much ado about one amino acid? Diabetologia 25: 457–459
Heding LG, Marshall MO, Persson B, Dahlquist G, Thalme B, Lindgren F, Akerblom HK, Rilva A, Knip M, Ludvigsson J, Stenhammar L, Strömberg L, Sovik O, Baevre H, Wefring K, Vidnes J, Kjaergard JJ, Bro P, Kaad PH (1984) Immunogenicity of monocomponent human and porcine insulin in newly diagnosed Type 1 (insulin-dependent) diabetic children. Diabetologia 27: 96–98
Berner Datenbuch der Pädiatrie (1985) 2nd edn. Gustav Fischer, Stuttgart New York, pp 93–143
Melani F, Ditschuneit H, Bartelt KM, Friedrich H, Pfeiffer EF (1965) Über die radioimmunologische Bestimmung von Insulin im Blut. Klin Wochenschr 43: 1000–1007
Christiansen AH (1973) Radioimmunoelectrophoresis in the determination of insulin binding to IgG-methodological studies. Horm Metab Res 5: 147–154
Bottazzo GF, Christensen AF, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet II: 1279–1282
Garotta G, Neri TM (1981) HLA-DR typing by complement-dependent B lymphocyte lysis. In: Lefkovits I, Pernis B (eds) Immunological methods II. Academic, New York, pp 163–185
Hoogwerf BJ, Rich SS, Barbosa JJ (1985) Meal-stimulated Cpeptide and insulin antibodies in type 1 diabetic subjects and their nondiabetic siblings characterized by HLA-DR antigens. Diabetes 34: 440–445
Ludvigsson J, Samuelsson U, Beauforts C, Deschamps I, Dorchy H, Drash A, Francois R, Herz G, New M, Schober E (1986) HLA-DR 3 is associated with a more slowly progressive form of Type 1 (insulin-dependent) diabetes. Diabetologia 29: 207–210
Knip M, Ilonen J, Mustonen A, Akerblom HK (1986) Evidence of an accelerated B-cell destruction in HLA-Dw3/Dw4 heterozygous children with Type 1 (insulin-dependent) diabetes. Diabetologia 29: 347–351
Hürter P, von Schütz W, Zick R, Stolzenbach K (1985) Klinische Erfahrungen mit der Substitution biosynthetischen Humaninsulins bei Kindern und Jugendlichen mit Typ-1-Diabetes. Monatschr Kinderheilk 133: 277–283
Akerblom HK, Mäkelä AL (1977) Insulin antibodies in the serum of diabetic children treated from the diagnosis of the disease with highly purified insulins. Acta Paediatr [Suppl 270]: 69–79
Ludvigsson J (1984) Insulin antibodies in diabetic children treated with monocomponent porcine insulin from the onset: relationship to B-cell function and partial remission. Diabetologia 26: 138–141
Schernthaner G, Ludwig H, Mayr WR (1979) Immunoglobulin G-insulin antibodies and immune region-associated alloantigens in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 48: 403–407
Reeves WG, Barr D, Douglas CA, Gelsthorpe K, Hanning I, Skene A, Wells L, Wilson RM, Tattersall RB (1984) Factors governing the human immune response to injected insulin. Diabetologia 26: 266–271
Almer LO, Ekberg G, Fankhauser S, Home PD, Worth R, Sailer S, Kurtz AB, Christy M (1985) A prospective study of the immunogenicity of porcine insulin in HLA-typed new insulin-treated diabetics. Diabetes Res 2: 221–224
Colombani J, Lepage V (1984) HLA monoclonal antibody registry: third listing. Tissue Antigens 24: 209–214
Lepage V, Alcalay D, Douay C, Mallet C, Loiseau P, Degos L, Colombani M, Colombani J (1985) Evidence for a new HLA class II determinant present on cells from HLA-DR1 and/or — DR4 individuals. Tissue Antigens 25: 96–102
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Zuppinger, K., Aebi, C., Fankhauser, S. et al. Comparison of human and porcine insulin therapies in children with newly diagnosed diabetes mellitus. Diabetologia 30, 912–915 (1987). https://doi.org/10.1007/BF00295873
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DOI: https://doi.org/10.1007/BF00295873