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Partial inversion of the secondary constriction of chromosome 9. Does it exist?

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Summary

Pericentric inversion of chromosome 9, a common abnormality, has been much studied because of its possible genetic effect. Apart from total inversion, in which the whole heterochromatic segment of chromosome 9 appears to be situated on the short arm, some authors describe partial inversion, in which the heterochromatin is found partly on the long arm and partly on the short arm.

Our study indicates that firstly, the heterochromatic segment of chromosome 9 is composed of two biochemically different subunits: the heterochromatin of the centromere itself and the heterochromatin of the secondary constriction. Secondly, it suggests that partial inversion of the secondary constriction of chromosome 9 is an unusual event, as the majority of published cases can be interpreted as the result of an increase in the centromeric heterochromatin without alteration of the secondary constriction.

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Authors and Affiliations

  1. Centre de Génétique Médicale, Hôpital d'Enfants de la Timone, F-13385, Marseille Cedex 5, France

    M. G. Mattei, J. F. Mattei, M. Guichaoua & F. Giraud

  2. INSERM U.242, Hôpital d'Enfants de la Timone, F-13385, Marseille Cedex 5, France

    M. G. Mattei, J. F. Mattei, M. Guichaoua & F. Giraud

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  1. M. G. Mattei
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  2. J. F. Mattei
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  3. M. Guichaoua
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  4. F. Giraud
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Supported by grants from INSERM (A.T.P. 79-110)

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Mattei, M.G., Mattei, J.F., Guichaoua, M. et al. Partial inversion of the secondary constriction of chromosome 9. Does it exist?. Hum Genet 59, 310–316 (1981). https://doi.org/10.1007/BF00295463

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  • DOI: https://doi.org/10.1007/BF00295463

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