Abstract
Copper sulfate, given orally in an emetic dose, decreased the absorption of therapeutic doses of acetylsalicylic acid or lithium carbonate, more than was expected judging from the recovery of salicylic acid in the vomit. Ten volunteers participitated.
Zusammenfassung
Die perorale Zufuhr von Kupfersulfat in emetischen Dosen reduziert die Resorption therapeutischer Dosen von Acetylsalicylsäure, beziehungsweise Lithiumcarbonat, mehr als von der Ausbeute an Salicylsäure im Erbrochenen her erwartet wurde. Zehn freiwillige Versuchspersonen waren beteiligt.
Similar content being viewed by others
References
Amdisen, A.: Serum lithium determinations for clinical use. Scand. J. clin. Lab. Invest. 20, 104–108 (1967)
Alpert, J. J., Heagarty, M. C.: Evaluation of a program for distribution of ipecac syrup for emergency home management of poison ingestions. J. Pediat. 69, 142–146 (1966)
Arnold, F. J., Jr., Hodges, J. B., Jr., Barta, R. A., Jr., Spector, S., Sunshine, I., Wedgewood, R.: Evaluation of the efficacy of lavage and induced emesis in the treatment of salicylate poisoning. Pediatrics 23, 286–301 (1959)
Burke, M.: Treatment of the poisoned child. Arch. Dis. Childh. 45, 731 (1970)
Cashman, T. M., Shirkey, H. C.: Emergency management of poisoning. Pediat. Clin. N. Amer. 17, 525–534 (1970)
Chirigos, M. A., Udenfriend, S.: A simple fluorometric procedure for determining salicylic acid in biologic tissues. J. Lab. clin. Med. 54, 769–772 (1959)
Corby, D. G., Decker, W. J., Moran, M. J., Payne, C. E.: Clinical comparison of pharmacologic emetics in children. Pediatrics 42, 361–364 (1968)
Decker, W. J., Shpall, R. A., Corby, D. G., Combs, H. F., Payne, C. E.: Inhibition of aspirin absorption by activated charcoal and apomorphine. Clin. Pharmacol. Ther. 10, 710–713 (1969)
Dreisbach, R. H.: Handbook of poisoning, 8th ed., p. 371. Los Altos: Lange 1974
Fairbanks, V. F.: Copper sulfate — induced hemolytic anemia. Arch, intern. Med. 120, 428–432 (1967)
Gosselin, R. E., Smith, R. P.: Trends in the therapy of acute poisonings. Clin. Pharmacol. Ther. 7, 279–299 (1966)
Holtzman, N. A., Haslam, R. H. A.: Elevation of serum copper following copper sulfate as an emetic. Pediatrics 42, 189–193 (1968)
Karlsson, B., Norén, L.: Ipecacuanha and copper sulfate as emetics in intoxications in children. Acta paediat. (Uppsala) 54, 331–335 (1965)
Koefoed-Johnsen, V., Ussing, H. H.: The nature of the frog skin potential. Acta physiol. scand. 42, 298–308 (1958)
Levy, G., Yaffe, S. J.: The study of salicylate pharmacokinetics in intoxicated infants and children. Clin. Toxicol. 1, 409–424 (1968)
Løchte, J.: Induced vomiting after accidental poisoning in childhood. Ugeskr. Læg. 133, 1770–1773 (1971)
Mofenson, H. C., Greensher, J.: The nontoxic ingestion. Pediat. Clin. N. Amer. 17, 583–590 (1970)
Prescott, L. F.: Pathological and physiological factors affecting drug absorption, distribution, elimination and response in man. In: Concepts in biochemical pharmacology (eds. J. R. Gillette, J. R. Mitchell), pp. 234–254. Berlin-Heidelberg-New York: Springer 1975
Schubert, J.: The relationship of metal-binding to salicylate action. In: Metal-binding in medicine (eds. M. J. Seven, L. A. Johnson), p. 325. Philadelphia: Lippincott 1960
Shirkey, H. C.: Ipecac syrup. Its use as an emetic in poison control. J. Pediat. 69, 139–141 (1966)
Yaffe, S. S., Sjöquist, F., Alvar, G.: Pharmacological principles in the management of accidental poisoning. Pediat. Clin. N. Amer. 17, 495–507 (1970)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lindkær-Jensen, S., Nellemann-Sørensen, P. Inhibition of salicylate and lithium absorption in the human intestine by copper sulfate. Arch. Toxicol. 35, 175–179 (1976). https://doi.org/10.1007/BF00293564
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00293564