Abstract
Eight new loci have been assigned to sheep Chromosome (Chr) 1q by use of a chromosomally characterized minipanel of sheep x hamster cell hybrids. Four loci, which have been mapped to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1). The other four loci, on human Chr 21, include interferon alpha receptor (IFNAR); interferon inducible protein p78, murine (MX1); collagen type VI, alpha 1 (COL6A1); and S100 protein, beta polypeptide (S100B). All of these loci, except GLUT2 and MX1, have been mapped onto bovine Chr 1 or are syntenic with loci on this chromosome. The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allore, R., Hanlon, D., Price, R., Neilson, K., Willard, H.F., Cox, D.R., Marks, A., Dunn, R.J. (1988). Gene encoding the B subunit of S100 protein is on chromosome 21: implications for Downs Syndrome. Science, 239, 1311–1313.
Ansari, H.A., Pearce, P.D., Maher, D.W., Malcolm, A.A., Broad, T.E., (1993). Resolving ambiguities in the karyotype of the domestic sheep (Ovis aries). Chromosoma 102, 340–347.
Ansari, H.A., Pearse, P.D., Maher, D.W., Malcolm, A.A., Wood, N.J., Phua, S.H., Broad, T.E. (1994). Regional mapping of loci from human chromosome 2q to sheep chromosome 2q. Genomics 20, 122–124.
Barendse, W., Armitage, S.M., Ryan, A.M., Moore, S.S., Clayton, D., Georges, M., Womack, J.E., Hetzel, J. (1993). A genetic map of DNA loci on bovine chromosome 1. Genomics 18, 602–608.
Barendse, W., Armitage, S.M., Kossarek, L.M., Shalom, A., Kirkpatrick, B.W., Ryan, A.M., Clayton, D., Li, L., Neibergs, H.L., Zhang, N., Grosse, W.M., Weiss, J., Creighton, P., McCarthy, F., Ron, M., Teale, A.J., Fries, R., McGraw, R.A., Moore, S.S., Georges, M., Soller, M., Womack, J.E., Hetzel, D.J.S. (1994). A genetic linkage map of the bovine genome. Nature Genet. 6, 227–237.
Bishop, M.D., Kappes, S.M., Keele, J.W., Stone, R.T., Sunden, S.L.F., Hawkins, G.A., Toldo, S.S., Fries, R., Gross, M.D., Yoo, J., Beattie, C.W. (1994). A genetic linkage map for cattle. Genetics 136, 619–639
Broad, T.E., Burkin, D.J., Cambridge, L.M., Maher, D.W., Lewis, P.E., Ansari, H.A., Pearce, P.D., Jones, C. (1994). Assignment of five loci from human chromosome 8q onto sheep chromosome 9. Cytogenet. Cell Genet., in press.
Burkin, D.J., Morse, H.G., Broad, T.E., Pearce, P.D., Ansari, H.A., Lewis, P.E., Jones, C. (1993). Mapping the sheep genome: production of characterized sheep x hamster cell hybrids. Genomics 16, 466–472.
Carpenter, M.A., Broad, T.E. (1993). The cDNA of horse transferrin. Biochim. Biophys. Acta 1173, 230–232.
Crawford, A.M., Montgomery, G.W., Brown, T.M., Swarbrick, P.A., Penty, J.M., Mathias, H.C. (1992). Linkage mapping of microsatellite on the sheep genome. Anim. Genet. 23(Suppl. 1), 95.
Crawford, A.M., Montgomery, G.W., Pierson, C.A., Brown, T., Dodds, K.G., Sunden, S.L.F., Henry, H.M., Ede, A.J., Swarbrick, P.A., Berryman, T., Penty, J.M., Hill, D.F. (1994). Sheep linkage mapping: nineteen linkage groups derived from the analysis of paternal half-sib families. Genetics, in press.
Drinkwater, R.D., Johnson, S.E., Barendse, W., Harrison, B., Womack, J.E., Hetzel, D.J.S. (1994). Isolation and mapping of a single locus microsatellite sequence marker to 1q36-qter and synteny group 10 in cattle, and to 1q36-qter in sheep. Genomics 19, 149–152.
Echard, G., Broad, T.E., Hill, D.F., Pearce, P.D. (1994). Present status of the ovine gene map (Ovis aries): comparison with the bovine map (Bos taurus). Mamm. Genome, in press.
Eldridge, F.E. (1985). Sheep and goat chromosomes. In Cytogenetics of Livestock, Westport, Conn.: AVI Publishing Co Inc., pp. 189–218.
Ford, C.E., Pollock, D.L., Gustavsson, I. (1980). Proceedings of the first international conference for the standardization of banded karyotypes of domestic animals. Reading 1976. Hereditas 92, 145–162.
Friedl, R., Rottmann, O.J. (1994). Assignment of the bovine uridine monophosphate synthase gene to bovine chromosome region 1q34–36 by FISH. Mamm. Genome 5, 38–40.
Fries, R., Eggen, A., Womack, J.E. (1993). The bovine genome map. Mamm. Genome 4, 405–428.
Fukumoto, H., Seino, S., Imura, H., Seino, Y., Eddy, R.L., Fukushima, Y., Byers, M.G., Shows, T.B., Bell, G.I. (1988). Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc. Natl. Acad. Sci. USA 85, 5435–5438.
Green, F., Edwards, Y., Hauri, H-P., Povey, S., Ho, M.W., Pinto, M., Swallow, D. (1987). Isolation of a cDNA probe for human jejunal brushborder hydroxylase, sucrase-isomaltase, and assignment of the gene locus to chromosome 3. Gene 57, 101–110.
Horisberger, M.A., Wathelet, M., Szpirer, J., Szpirer, C., Islam, Q., Levan, G., Huez, G., Content, J. (1988). cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene. Somat. Cell Mol. Genet. 14, 123–131.
ISCNDA 1989 (1990). International System for Cytogenetic Nomenclature for Domestic Animals. Cytogenet. Cell Genet. 53, 65–79.
McAlpine, P.J., Shows, T.B., Boucheix, C., Pericak-Vance, M.A., Anderson, W.A. (1993). The 1992 catalog of mapped genes and report of the nomenclature committee. Genome Priority Rep. 1, 11–142.
Moore, S.S., Byrne, K., McCarthy, F., Barendse, W., Womack, J.E., Hetzel, D.J.S. (1994). Characterization of 65 bovine microsatellites. Mamm. Genome 51, 74–80.
Morishita, K., Parganas, E., Bartholomew, C., Sacchi, N., Valentine, M.B., Raimond, S.C., LeBeau, M.M., Ihle, J.N. (1990). The human Evi-1 gene is located on chromosome 3q24–q28 but is not rearranged in three cases of acute nonlymphocytic leukemias containing t(3;5)(q25;q34) translocations. Oncogene Rep. 5, 221–231.
O'Brien, S.J., Peters, J., Searle, A., Womack, J., Marshall-Graves, J. (1993a). Report of the committee on comparative gene mapping. Genome Priority Rep. 1, 758–809.
O'Brien, S.J., Womack, J.E., Lyons, L.A., Moore, K.J., Jenkins, N.A., Copeland, N.G. (1993b). Anchored reference loci for comparative genome mapping in mammals. Nature Genet. 3, 103–112.
Parson, Y.M., Piper, L.R., Cooper, D.W. (1994). Linkage relationships between keratin associated protein (KRTAP) genes and growth hormone in sheep. Genomics 20, 500–502.
Ryan, A.M., Gallagher, D.S., Schoeber, S., Schwenger, B., Womack, J.E. (1994). Somatic cell mapping and in situ localization of the bovine uridine monophosphate synthase (UMPS) gene. Mamm. Genome 51, 46–47.
Yang, F., Naylor, S.L., Lum, J.B., Cutshaw, S., McCombs, J.L., Naberhaus, K.H., McGill, J.R., Adrian, G.S., Moore, C.M., Barnett, D.R., Bowman, B.H. (1986). Characterization, mapping, and expression of the human ceruloplasmin gene. Proc. Natl. Acad. Sci. USA 83, 3257–3261.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Broad, T.E., Burkin, D.J., Cambridge, L.M. et al. Four human Chromosome 3q and four human Chromosome 21 loci map onto sheep Chromosome 1q. Mammalian Genome 6, 202–205 (1995). https://doi.org/10.1007/BF00293014
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00293014