Summary
A locus, LP, that determines quantitative variation of Lp(a) lipoprotein phenotypes is linked to the plasminogen (PLG) locus (peak lod score =12.73). This linkage relationship assigns a locus with alleles that have an affect on risk for coronary artery disease to the long arm of chromosome 6.
Similar content being viewed by others
References
Berg K (1963) A new serum type in man: the Lp system. Acta Pathol Microbiol Scand 59:369–382
Berg K (1979) Linkage studies of the LP polymorphism. Cytogenet Cell Genet 25:136
Berg K (1983) Genetics of coronary artery disease. Prog Med Genet 5:35–90
Bersot TP, Innerarity TL, Pitas RE, Rall SC Jr, Weisgraber KH, Mahley RW (1986) Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein(a) and that cause lipid accumulation in macrophages. J Clin Invest 77: 622–630
Eaton DL, Fless GM, Kohr WJ, McLean JW, Xu Q-T, Miller CG, Lawn RM, Scanu AM (1987) Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen. Proc Natl Acad Sci USA 84:3224–3228
Gries A, Nimpf J, Nimpf M, Wurm H, Kostner GM (1987) Free and Apo B-associated Lpa-specific protein in human serum. Clin Chim Acta 164:93–100
Guyton JR, Dahlew GH, Patsch W, Kautz JA, Gotto AM Jr (1985) Relationship of plasma lipoprotein Lp(a) levels to race and to apolipoprotein B. Arteriosclerosis 5:265–272
McLean JW, Tomlinson JE, Kuang W-J, Eaton OL, Chen EY, Fless GM, Scanu AM, Lawn RM (1981) cDNA sequence of human apolipoprotein (a) is homologous to plasminogen. Nature 330: 132–137
Morton NE (1955) Sequential tests for the detection of linkage. Am J Hum Genet 7:277–318
Morton NE, Berg K, Dahlen G, Ferrell RE, Rhoads G (1985) Genetics of the Lp lipoprotein in Japanese-Americans. Genet Epidemiol 2: 113–121
Murray JC, Sadler E, Eddy RL, Shows TB, Buetow KH (1985) Evidence for assignment of plasminogen (PLG) to chromosome 6, not chromosome 4. Cytogenet Cell Genet 40:709
Murray JC, Buetow KH, Donovan M, Hornung S, Motulsky AG, Disteche C, Dyer K, Swisshelm K, Anderson J, Giblett E, Sadler E, Eddy R, Shows TB (1987) Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26–6q27. Am J Hum Genet 40:338–350
Namboodiri KK, Elston RC, Go RLP, Berg K, Haines C (1977) Linkage relationships of Lp and Ag serum lipoproteins with 25 polymorphic markers. Hum Genet 37:291–297
Parra H-J, Luyéyé I, Bouramoué C, Demarquilly C, Fruchart J-C (1987) Black-white differences in serum Lp(a) lipoprotein levels. Clin Chim Acta 167:27–31
Rhoads GG, Dahlen G, Berg K, Morton N, Dannenberg AL (1986) Lp(a) lipoprotein as a risk factor for myocardial infarction. JAMA 256:2540–2544
Schultz JS, Shreffler DC, Sing CF (1974) The genetics of the Lp antigen. I. Its quantitation and distribution in a sample population. Ann Hum Genet 38:39–46
Sing CF, Schultz JS Shreffler DC (1974) The genetics of the Lp antigen. II. A family study and proposed models of genetic control. Ann Hum Genet 38:47–56
Swisshelm K, Dyer K, Sadler F, Disteche C (1985) Localization of the plasminogen gene (PLG) to the distal portion of the long arm of human chromosome 6 by in situ hybridization. Cytogenet Cell Genet 40:756
Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmier HG, Seitz C (1987) Lp(a) glycoprotein phenotypes J Clin Invest 80:458–465
Weitkamp LR (1971) Human autosomal linkage groups. In: Proceedings of the 4th International Congress on Human Genetics 1971. (International congress series, vol 250) Excerpta Medica, Amsterdam, pp 445–460
Weitkamp LR, Costello-Leary P, Guttormsen SA (1983) Equine marker genes: polymorphism for plasminogen. Anim Blood Groups Biochem Genet 14:219–223
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Weitkamp, L.R., Guttormsen, S.A. & Schultz, J.S. Linkage between the loci for the Lp(a) lipoprotein (LP) and plasminogen (PLG). Hum Genet 79, 80–82 (1988). https://doi.org/10.1007/BF00291716
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00291716