Summary
Chromosomal Q-polymorphism was studied in 198 Kirghiz subjects (98 males and 100 females) from one high-altitude isolate located in the south-eastern part of Kirghizia. Small samples of mountaineers (N=37) and volunteer subjects (N=34) were also studied. The samples studied did not differ significantly from each other in the relative frequencies of chromosomal variants in 12 loci of seven Q-polymorphic autosomes. The mean number of Q variants per individual in the populations ranged from 1.3 to 2.0. No sex differences were found in the frequencies of Q variants. The observed homo- and heteromorphic frequencies agreed with those predicted by the law of Hardy-Weinberg. The possible selective value of chromosomal Q heterochromatin material in the adaptation of human populations to high-altitude climate is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Al-Nassar KE, Palmer CG, Conneally PM, Pao-Lo Yu (1981) The genetic structure of the Kuwaiti population. II. The distribution of Q-band chromosomal heteromorphism. Hum Genet 57:423–427
Buckton KE, O'Riordan ML, Jacobs PA, Robinson JA, Hill R, Evans HJ (1976) C- and Q-band polymorphisms in the chromosomes of three human populations. Ann Hum Genet 40:90–112
Geraedts JPM, Pearson PL (1974) Fluorescent chromosome polymorphism: frequencies and segregation in a Dutch population. Clin Genet 6:247–257
Ibraimov AI (1983a) Human chromosomal polymorphism. VII. The distribution of chromosomal Q-polymorphic bands in different human populations. Hum Genet 63:384–391
Ibraimov AI (1983b) Chromosome preparations of human whole lymphocytes — an improved technique. Clin Genet 24:240–242
Ibraimov AI, Mirrakhimov MM (1979) PTC-testing ability in populations living in Kirghizia with special reference to hypersensitivity: its relation to sex and age. Hum Genet 46:97–105
Ibraimov AI, Mirrakhimov MM (1982a) Human chromosomal polymorphism. III. Chromosomal Q-polymorphism in Mongoloids of Northern Asia. Hum Genet 62:252–257
Ibraimov AI, Mirrakhimov MM (1982b) Human chromosomal polymorphism. IV. Chromosomal Q-polymorphism in Russians living in Kirghizia. Hum Genet 62:258–260
Ibraimov AI, Mirrakhimov MM (1982b) Human chromosomal polymorphism. in African populations. Hum Genet 62:261–265
Ibraimov AI, Mirrakhimov MM (1983) Human chromosomal polymorphism. VI. Chromosomal Q-polymorphism in Turkmen of the Kara-Kum desert of Central Asia. Hum Genet 63:380–383
Ibraimov AI, Mirrakhimov MM, Nazarenko SA, Axenrod EI, Akbanova GA (1982) Human chromosomal polymorphism. I. Chromosomal Q-polymorphism in Mongoloid populations of Central Asia. Hum Genet 60:1–7
Ibraimov AI, Mirrakhimov MM, Axenrod EI (1986) Human chromosomal polymorphism. VIII. Chrosomal Q-polymorphism in the Yakut of Eastern Siberia. Hum Genet 73:147–150
Lubs HA, Patil SR, Kimberling WJ, Brown J, Cohen M, Hecht F, Myrianthopoulos N, Summit RL (1977) Q-and C-banding polymorphisms in 7 and 8-year-old children: recial differences and clinical significances. In: Hook EB, Porter IH (eds) Population cytogenetics. Academic Press, New York London, pp 133–159
McKenzie WH, Lubs HA (1975) Human Q and C chromosomal variations: distribution and incidence. Cytogenet Cell Genet 14:97–115
Mirrakhimov MM (1978) Biological and physiological characteristics of the high-altitude natives of Tien-Shan and the Pamirs. In: Baker PT (ed) The biology of high altitude people. Cambridge University Press, Cambridge, pp 329–349
Müller H, Klinger HP, Glasser M (1975) Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual. Cytogenet Cell Genet 15:239–255
Paris Conference (1971) Supplement (1975) Standardization in human cytogenetics. Birth Defects XI:1–84
Van Dyke DL, Palmer CG, Nance WE, Yu Pao-Lo (1977) Chromosome polymorphism and twin zygosity. Am J Hum Genet 29:431–447
Yamada K, Hasegawa T (1978) Types and frequencies of variant chromosomes in a Japanese population. Hum Genet 44:89–98
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ibraimov, A.I., Mirrakhimov, M.M., Axenrod, E.I. et al. Human chromosomal polymorphism. Hum Genet 73, 151–156 (1986). https://doi.org/10.1007/BF00291606
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00291606