Abstract
The azo dye tartrazine, after dosing by gavage, is transformed by rats into urinary metabolites which exert dose-dependent mutagenic activities in the Ames test with Salmonella typhimurium TA 98 after addition of rat liver metabolizing enzymes (S9 mix). The strain TA 100 showed no mutagenic response.
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References
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Abbreviation: FD & C Yellow No. 5 (5-oxo-1-(p-sulphophenyl)-4-(sulphophenylazo)-2-pyrazoline-3-carboxylic acid, trisodium salt)
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Henschler, D., Wild, D. Mutagenic activity in rat urine after feeding with the azo dye tartrazine. Arch Toxicol 57, 214–215 (1985). https://doi.org/10.1007/BF00290891
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DOI: https://doi.org/10.1007/BF00290891