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Chelation in metal intoxication XVII: antidotal efficacy of polyaminocarboxylic acids on acute chromate toxicity

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Abstract

Some polyaminocarboxylic acids containing amino and carboxyl groups as metal binding sites in different structural arrangements were evaluated for their relative efficacy in protecting against acute chromate intoxication in mice. Nitrilotriacetic acid (NTA) and 1,2 cyclohexylenediamine tetraacetic acid (CDTA) were most effective in preventing mortality (50–70%) due to a lethal dose of potassium chromate at one-tenth of their respective LD50.

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References

  • Behari JR, Tandon SK (1980) Chelation in Metal Intoxication. VIII. Removal of chromium from organs of potassium chromate administered rats, Clin Toxicol 16: 33–40

    Google Scholar 

  • Goldstein A (1964) Biostatistics: An introductory text. The Macmillan Company, New York p 101

    Google Scholar 

  • Langard S (1978) Chromium. In: Waldron LA (ed) Metals in the environment, Academic Press, London

    Google Scholar 

  • Nagahashi M, Wada O, Ono T, Yamaguchi N, Takeo K (1974) Dose-response relationship between given doses of heavy metals and sulphydryl group contents in the special protein fractions excreted from tissues of mice, Indust Health 12: 31–36

    Google Scholar 

  • Samitz MH, Shrager JD, Katz SA (1962) Studies on prevention of injurious effects of chromates in industry. Indus Med Surg 31: 427–432

    Google Scholar 

  • Schlatter C, Kissling U (1973) Akute, tödliche Vergiftung mit bichromat, Beitr Gerichtl Med 30: 382–388

    Google Scholar 

  • Shakhnazarov AM (1974) Histochemical determination of alkaline phosphatase in the kidneys under severe chromium poisoning and unithiol treatment. Vapr Eksp Klin Ter Profil Prom Intoksikatsii 126–130 (Russ) Chem Abstr 84: 13126e (1976)

  • Tandon SK (1982) Organ Toxicity of Chromium in Animals, In: Langard S (ed) Biological and environmental aspects of chromium Elsevier/North Holland Biomedical Press, Amsterdam, Netherlands, pp 209–220

    Google Scholar 

  • Tandon SK, Khandelwal Shashi (1982) Chelation in metal Intoxication. XII. Antidotal efficacy of chelating agents on acute toxicity of manganese, Arch Toxicol 50: 19–25

    Google Scholar 

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Authors and Affiliations

  1. Industrial Toxicology Research Centre, Post Box 80, Lucknow, India

    S. K. Tandon & Laj Srivastava

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  1. S. K. Tandon
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  2. Laj Srivastava
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Tandon, S.K., Srivastava, L. Chelation in metal intoxication XVII: antidotal efficacy of polyaminocarboxylic acids on acute chromate toxicity. Arch Toxicol 57, 212–213 (1985). https://doi.org/10.1007/BF00290890

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  • DOI: https://doi.org/10.1007/BF00290890

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