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Genetic studies of complement C4 in man

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Summary

A C4 variant found in about 5% of the population is described. The fast-moving part of this variant is governed by an allele (F x) codominant to F. The F x allele is in very strong linkage disequilibrium with HLA-B17 as the linkage disequilibrium parameter accounted for nearly 100% of the haplotype frequency of B17, F x. The strong association is also evidenced by the study of 11 families segregating for the F x allele. There was no instance of recombination between C4 and HLA in 36 informative meioses.

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Authors and Affiliations

  1. Institute of Human Genetics, University of Aarhus, The Bartholin Building, DK-8000, Aarhus C, Denmark

    G. B. Petersen & Inger Juncker Sørensen

  2. Tissue Typing Laboratory, University of Aarhus, DK-8000, Aarhus C, Denmark

    Lisbeth Buskjær & L. U. Lamm

Authors
  1. G. B. Petersen
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  2. Inger Juncker Sørensen
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  3. Lisbeth Buskjær
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  4. L. U. Lamm
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Petersen, G.B., Sørensen, I.J., Buskjær, L. et al. Genetic studies of complement C4 in man. Hum Genet 53, 31–36 (1979). https://doi.org/10.1007/BF00289447

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  • DOI: https://doi.org/10.1007/BF00289447

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