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Die freisetzung von Acetylcholin durch die motorischen Nervenendigungen

Deutung experimenteller Befunde durch ein Analogmodell

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Summary

  1. 1.

    Hypotheses concerning the transport of acethylcholine (Ach) and of changes in the coefficient of release during and after repetitive stimulation are presented. These hypotheses are based on the conception that an action potential releases a certain amount of immediately available Ach from a reservoir at the motor nerve ending.

  2. 2.

    Corresponding to these hypotheses an electrical analog model was conceived. The differential equations deduced from the model were programmed on an analog computer.

  3. 3.

    The changes in Ach-release during and after repetitive stimulation, known from biological experiments either with Curare- or with Magnesium-blocked preparations, could be reproduced qualitatively when changing only one parameter of the model.

  4. 4.

    For the purposes of quantitative simulation, data from various biological experiments, partly from other authors, partly from our own laboratory, were used. In most of the experiments the curves derived from the model are found to be within the standard deviation of the biological data.

  5. 5.

    It is concluded that a system of lesser complexity does not equally well lead to a simulation of the biological data.

  6. 6.

    The analog relationships between the model and the biological processes are discussed. By use of the model it may be possible to simulate the release of transmitter at other synapses too.

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  1. Physiologisches Institut der Universität Berlin, Germany

    Peter Kruckenberg

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  1. Peter Kruckenberg
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Mit Unterstützung der Deutschen Forschungsgemeinschaft (Ga 37/15).

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Kruckenberg, P. Die freisetzung von Acetylcholin durch die motorischen Nervenendigungen. Kybernetik 4, 113–130 (1968). https://doi.org/10.1007/BF00288544

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