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Relative induction of molecular forms of cytochrome P-450 in γ-hexachlorocyclohexane exposed rat liver microsomes

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Abstract

The effect of γ-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied. Induced proteins were characterized by “Western” blot analysis, using anticytochrome P-450 antibodies. It was observed that HCH is a “mixed-type” inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold.

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  1. Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Post Box No. 80, 226001, Lucknow, India

    Ashwani Kumar & Prem Prakash Dwivedi

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  1. Ashwani Kumar
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  2. Prem Prakash Dwivedi
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Kumar, A., Dwivedi, P.P. Relative induction of molecular forms of cytochrome P-450 in γ-hexachlorocyclohexane exposed rat liver microsomes. Arch Toxicol 62, 479–481 (1988). https://doi.org/10.1007/BF00288355

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  • DOI: https://doi.org/10.1007/BF00288355

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