Abstract
The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.
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The present study was carried out by the order of the Federal Ministry for Research and Technology (BMFT)
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Grimmer, G., Brune, H., Dettbarn, G. et al. Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application. Arch Toxicol 62, 401–405 (1988). https://doi.org/10.1007/BF00288341
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DOI: https://doi.org/10.1007/BF00288341