Summary
Chromosome 17ps was identified in the mother and daughter but not the father of a normal family with no history of congenital abnormality. In addition to G-band and Ag-NOR staining, previously used to study this abnormality, we applied N-band and C-band techniques. Our results showed that 17ps has no demonstrable ribosomal cistron or constitutive heterochromatin.
Similar content being viewed by others
References
Bloom, S. E., Goodpasture, C.: An improved technique for selective silver staining of nucleolar organizer regions in human chromosomes. Hum. Genet. 34, 199–206 (1976)
Croce, C. M.: Assignment of the integration site for Simian virus 40 to chromosome 17 in GM54Va, a human cell line transformed by Simian virus 40. Proc. Natl. Acad. Sci. (USA) 74, 315–318 (1977)
Croce, C. M., Talavera, A., Basilico, C., Miller, O. J.: Suppression of production of mouse 28S rRNA in mouse-human hybrids segregating mouse chromosomes. Proc. Natl. Acad. Sci. (USA) 74, 694–697 (1977)
Funaki, K., Matsui, S., Sasaki, M.: Location of nucleolar organizers in animal and plant chromosomes by means of an improved N-banding technique. Chromosoma 49, 357–370 (1975)
Goodpasture, C., Bloom, S. E.: Visualization of nucleolar organizer regions in mammalian chromosomes using silver staining. Chromosoma 53, 37–50 (1975)
Hsu, T. C.: Constitutive heterochromatin (C-band) technique. In: Chromosome Identification —technique and applications in biology and medicine, T. Caspersson, L. Zech, eds., Nobel Symposium 23, 32–33 (1973)
Kaosaar, M. E., Mikelsaar, A.-V. N.: Chromosome investigation in married couples with repeated spontaneous abortions. Humangenetik 17, 277–283 (1973)
Kubien, E., Kleczkowska, A.: Familial occurrence of chromosome variant 17ph+. Clin. Genet. 12, 39–42 (1977)
McDougall, J. K.: Spontaneous and adenovirus type 12-induced chromosome aberrations in Fanconi's anemia fibroblasts. Int. J. Cancer 7, 526–536 (1971)
McDougall, J. K., Dunn, A. R., Jones, K. W.: In situ hybridization of adenovirus RNA and DNA. Nature 236, 346–348 (1972)
McDougall, J. K., Kucherlapati, R., Ruddle, F. H.: Localization and induction of the human thymidine kinase gene by adenovirus 12. Nature 245, 172–174 (1973)
Mikelsaar, A.-V. N., Tuur, S. J., Kaosaar, M. E.: Human karyotype polymorphism. I. Routine and fluorescent microscopic investigation of chromosomes in a normal adult population. Humangenetik 20, 89–101 (1973)
Miller, O. J., Miller, D. A., Dev, V. G., Tantravahi, R., Croce, C. M.: Expression of human and suppression of mouse nucleolus organizer activity in mouse-human somatic cell hybrids. Proc. Natl. Acad. Sci. (USA) 73, 4531–4531 (1976)
Oliver, N., Francke, U., Taylor, K. M.: Silver staining studies on the short arm variant of human chromosome 17. Hum. Genet. 42, 79–82 (1978)
Priest, J. H., Peakman, D. C., Patil, S. R., Robinson, A.: Significance of chromosome 17ps+ in three generations of a family. J. Med. Genet. 7, 142–147 (1970)
Sandstrom, M., Jenkins, E.: A 17p marker chromosome familial study. Ann. Genet. (Paris) 16, 267–269 (1973)
Schmid, E., Bauchinger, M.: Structural polymorphism in chromosome 17. Nature 221, 387–388 (1969)
Seabright, M.: The use of proteolytic enzymes for the mapping of structural rearrangements in the chromosomes of man. Chromosoma 36, 204–210 (1972)
Tharapel, A. T., Summitt, R. L.: Minor chromosome variations and selected heteromorphisms in 200 unclassifiable mentally retarded patients and 200 normal controls. Hum. Genet. 41, 121–130 (1978)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Au, W., Witek, J.A. Cytochemical analysis on a case of familial 17ps. Hum Genet 48, 195–199 (1979). https://doi.org/10.1007/BF00286904
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00286904