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The occurrence of antigenic determinants of human blood proteins in mammalian plasmas

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Summary

In an attempt to follow up the persistence of single antigenic determinants of plasma proteins, the patterns of their determinants as revealed by cross-reactions with human plasma were tested in man, chimpanzee, the rhesus monkey, ox, sheep, pig, guinea pig and rat. The proteins investigated include ceruloplasmin, α1-lipoproteins, fibrinogen, plasminogen, βC-A- and β 1E-globulins. The results are presented in the form of pedigrees for the different plasma proteins: The phylogenetical pathways of the single determinants of human plasma proteins can be followed up; phylogenetically old determinants can be distinguished from others, which are possibly younger. The sensitivity of immunological techniques, which have been shown to be able to demonstrate single base changes in the DNA, for evolution research at the molecular level is stressed.

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Authors and Affiliations

  1. Institute of Immunology and Serology, Heidelberg University, Heidelberg, Germany

    Klausdieter Bauer

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  1. Klausdieter Bauer
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Bauer, K. The occurrence of antigenic determinants of human blood proteins in mammalian plasmas. Hum Genet 8, 27–32 (1969). https://doi.org/10.1007/BF00286752

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  • DOI: https://doi.org/10.1007/BF00286752

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