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Mating between two balanced translocation carriers in two unrelated families

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Summary

Partial trisomy 9p and a 13/14 translocation occurred in the daughter of a t(5;9)(p15;p12) mother and a t(13;14) (p11;q11) father. Two additional offspring displayed a normal karyotype and a translocation trisomy 13 respectively. Two first cousins, selected for chromosome analysis because of a spontaneous abortion, were found to have an identical translocation t(14;21)(p11;q11). Their second pregnancy was monitored by midtrimester amniocentesis and disclosed a balanced fetus. The different zygotic chromosome constitutions and the counselling problems in the marriages between two balanced translocation carriers are discussed.

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Authors and Affiliations

  1. Cattedra di Genetica Umana, Università di Urbino, Urbino, Italia

    B. Dallapiccola

  2. Cattedra di Genetica Medica, Università “La Sapienza”, Roma, Italia

    L. Chessa, V. Brinchi, M. Frontali & E. Gandini

Authors
  1. B. Dallapiccola
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  2. L. Chessa
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  3. V. Brinchi
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  4. M. Frontali
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  5. E. Gandini
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Dallapiccola, B., Chessa, L., Brinchi, V. et al. Mating between two balanced translocation carriers in two unrelated families. Hum Genet 65, 165–168 (1983). https://doi.org/10.1007/BF00286655

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  • DOI: https://doi.org/10.1007/BF00286655

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