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Induction of intragenic mitotic recombination in yeast by hydroxylamine and its mutagenic specificity

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Summary

Hydroxylamine in 1 M concentration is capable of inducing mutations (Table 1) and recombination (Figs. 1–3) in yeast. It is postulated that HA-produced lesions in DNA are repaired and thus HA-induced mutations in yeast cannot be specific with respect to the type of base substitution; the recombinogenic ability of a mutagen can be considered as an indication that the lesions in DNA produced by this mutagen are repaired.

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Authors and Affiliations

  1. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

    Alexandra Putrament & Hanna Baranowska

  2. Institute of Biochemistry, ul. Rakowiecka 36, Warschau, Polen

    Alexandra Putrament

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  1. Alexandra Putrament
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  2. Hanna Baranowska
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Communicated by F. Kaudewitz

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Putrament, A., Baranowska, H. Induction of intragenic mitotic recombination in yeast by hydroxylamine and its mutagenic specificity. Molec. Gen. Genet. 111, 89–96 (1971). https://doi.org/10.1007/BF00286558

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  • DOI: https://doi.org/10.1007/BF00286558

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