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Properties of the cyclic AMP-dependent protein kinases in mouse mastocytoma cells

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Summary

The proportions of type I and type II protein kinases in PY815 mouse mastocytoma cells were shown to change following growth inhibition by prostaglandin E, and 3-isobutyl-l-methylxanthine. These changes included a large reduction in type I protein kinase consistent with a role for this isoenzyme as a positive effector of growth, a decrease in free cyclic AMP binding protein and an increase in type II protein kinase. Some properties of the fully activated isoenzymes are presented that may be important in determining their activity in vivo.

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Authors and Affiliations

  1. Dept. of Cell Biology, University of Auckland, Auckland, New Zealand

    John Smart & Ray Ralph

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  1. John Smart
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  2. Ray Ralph
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Smart, J., Ralph, R. Properties of the cyclic AMP-dependent protein kinases in mouse mastocytoma cells. Mol Cell Biochem 50, 107–113 (1983). https://doi.org/10.1007/BF00285637

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  • DOI: https://doi.org/10.1007/BF00285637

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