Summary
The subcutaneous tissue is generally considered as a potential site for the monitoring of intracorporal glucose concentration by means of implanted sensors. We studied the suitability of using the resulting signal from the interstitial glucose concentration as an input in a feedback-controlled system for insulin administration. Miniaturized glucose electrodes (amperometric glucose oxidase sensors for the measurement of hydrogen peroxide) were implanted in insulin-dependent diabetic dogs. The output of these sensors was fed into the controller of a bedside-type artificial B cell. Insulin was infused by the device intravenously on the basis of a proportional-differential algorithm. The glucose patterns were compared to identical experiments where feedback control was accomplished on the basis of paracorporal blood glucose measurement using the same algorithm. Normoglycaemia was restored and maintained in both sets of experiments and oral glucose loads were well compensated for. It is concluded that the apparent subcutaneous glucose concentration is appropriate as an input signal for an artificial B cell.
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Pfeiffer EF (1987) On the way to the automated (blood) glucose regulation in diabetic dogs: the dark past, the grey present and the rosy future. Diabetologia 30: 50–65
Turner APF, Pickup JC (1985) Diabetes mellitus: biosensors for research and management. Biosensors 1: 85–115
Shichiri M, Kawamori R, Goriya Y, Yamasaki Y, Nomura M, Hakui N, Abe H (1983) Glycaemic control in pancreatectomized dogs with a wearable artificial endocrine pancreas. Diabetologia 24: 179–184
Shichiri M, Kawamori R, Hakui N, Asakawa N, Yamasaki Y, Abe H (1984) The development of wearable-type artificial endocrine pancreas and its usefulness in glycaemic control of human diabetes mellitus. Biomed Biochem Acta 43: 561–568
Matthews DR, Bown E, Beck TW, Plotkin E, Lock L, Gosden E, Wickham M (1988) An amperometric needle-type glucose sensor tested in rats and man. Diab Med 5: 248–252
Shichiri M, Askawa N, Yamasaki Y, Kawamori R, Abe H (1986) Telemetry glucose monitoring device with needle-type glucose sensor: A useful tool for blood glucose monitoring in diabetic individuals. Diabetes Care 9: 298–301
Fischer U, Ertle R, Abel P, Rebrin K, Brunstein E, Hahn v. Dorsche H, Freyse EJ (1987) Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs. Diabetologia 30: 940–945
Shichiri M, Kawamori R, Hakui N, Yamasaki Y, Abe H (1984) Closed-loop glycemic control with a wearable artificial endocrine pancreas: variations in daily insulin requirements to glycemic response. Diabetes 33: 1200–1202
Fischer U, Besch W, Freyse EJ (1985) Canine C-peptide for characterization of experimental diabetes in dogs. Endocrine Exp 19: 139–145
Fischer U, Jutzi E, Bombor H, Freyse EJ, Salzsieder E, Albrecht G, Besch W, Bruns W (1980) Assessment of an algorithm for the artificial B-cell using the normal insulin glucose relationship in diabetic dogs and man. Diabetologia 18: 97–107
Freyse EJ, Hahn v. Dorsche H, Fischer U (1982) Low dose streptozotocin diabetes after partial pancreatectomy in dogs. Histological findings in a new type of experimental diabetes. Acta Biol Med Germ 41: 1203–1210
Fischer U, Abel P (1982) A membrane combination for implantable glucose sensor measurements in undiluted biological fluids. Trans Am Soc Artif Intern Organs XXVIII: 245–248
Abel P, Mueller A, Fischer U (1984) Experience with an implantable glucose sensor as a prerequisite of an artificial beta cell. Biomed Biochem Acta 43: 577–584
Lienert GA (1975) Verteilungsfreie Methoden in der Biostatistik, 2. Aufl. Anton Hain, Meisenheim
Horwitz DL (1979) Insulin responses to mixed meals: comparison of an artificial beta cell and normal beta cells. Horm Metab Res [Suppl] 8: 68–71
Radziuk J, McDonald TJ, Rubenstein D, Dupre J (1978) Initial splanchnic extraction if ingested glucose in normal man. Metabolism 27: 657–669
Sorensen JT, Clark KC, Hillman RS, Soeldner JS (1982) Use of a physiologic pharmacokinetic model of glucose homeostasis for assessment of performance requirements for improved insulin therapies. Diabetes Care 5: 148–157
Salzsieder E, Albrecht G, Jutzi E, Fischer U (1984) Estimation of individually adapted control parameters for an artificial beta cell. Biomed Biochim Acta 43: 585–596
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Rebrin, K., Fischer, U., Woedtke, T.v. et al. Automated feedback control of subcutaneous glucose concentration in diabetic dogs. Diabetologia 32, 573–576 (1989). https://doi.org/10.1007/BF00285330
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DOI: https://doi.org/10.1007/BF00285330