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Trisomy 18 in monozygotic twins

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Summary

We report a very rare case of a pair of monozygotic twins with trisomy 18 discordant for major anomalies. Our case contributes to published data on the role of nongenetic factors in the etiology of discordance of congenital malformations in genotypically identical twins. We stress the importance of accurate ultrasonic examination in reducing the number of caesarean sections to deliver trisomy 18 infants.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam-Dijkzigt, Erasmus University, Dr. Molewaterplein 40, NL-3015 GD, Rotterdam, The Netherlands

    A. F. P. Mulder, J. van Eyck & J. W. Wladimiroff

  2. Department of Pediatrics, Sophia Children's Hospital, Erasmus University, NL-3015 GD, Rotterdam, The Netherlands

    F. Groenendaal

Authors
  1. A. F. P. Mulder
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  2. J. van Eyck
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  3. F. Groenendaal
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  4. J. W. Wladimiroff
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Mulder, A.F.P., van Eyck, J., Groenendaal, F. et al. Trisomy 18 in monozygotic twins. Hum Genet 83, 300–301 (1989). https://doi.org/10.1007/BF00285179

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  • DOI: https://doi.org/10.1007/BF00285179

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