Summary
After intraperitoneal injection of 1,3-dimethyl-4-amino-5-nitroso-uracile in oily suspension (single dose 0,2 g/kg, total dose 3 g/kg) in Sprague-Dawley-rats a carcinogenic effect could not be found. After subcutaneous application (single dose 2 g/kg, total dose 16 g/kg) in 6 of 40 rats local sarcomas occurred at the site of application.
Zusammenfassung
Nach i. p. Injektion von 1,3-Dimethyl-4-amino-5-nitroso-uracil in öliger Suspension (Einzeldosis 0,2 g/kg; Gesamtdosis 3 g/kg) war bei Sprague-Dawley-Ratten eine carcinogene Wirkung nicht nachweisbar. Bei s. c. Applikation (Einzeldosis 2 g/kg; Gesamtdosis 16 g/kg) entstanden bei 6 von 40 Ratten lokale Sarkome an der Applikationsstelle.
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Literatur
Goodall,C.M., Lijinsky,W., Smillie,A.C.: Oncogenicity of p-Nitroso-N,N-dimethylaniline in rats. Proc. Univ. Otago Med. School 46, 68–70 (1968)
Mirvish,S.S. und Garcia,H.: 1-nitroso-5,6-dihydrouracil: induction of liver cell carcinomas and kidney adenomas in the rat. Z. Krebsforsch. 79, 304–308 (1973)
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Schmähl, D. Prüfung von 1,3-Dimethyl-4-amino-5-nitroso-uracil auf carcinogene Wirkung an Ratten. Z. Krebsforsch. 80, 297–299 (1973). https://doi.org/10.1007/BF00284364
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DOI: https://doi.org/10.1007/BF00284364